Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users

The Journal of Infectious Diseases
Manuel Sánchez de la TorreJoan Fibla

Abstract

Vitamin D receptor (VDR) participates in multiple immune functions. Here, we determined whether VDR gene-sequence variations are associated with intersubject differences in the risk of acquiring human immunodeficiency virus type 1 (HIV-1) infection. We assessed this in 460 males exposed to HIV-1 by injection drug use (335 infected and 125 uninfected) and 124 seronegative healthy subjects. Multilocus logistic regression analysis revealed haplotypes for rs11568820, rs4516035, rs10735810, rs1544410, and rs17878969 polymorphisms showing association with protection to HIV-1 infection (odds ratio, 0.4 [95% confidence interval, 0.22-0.72]; P = .0025), which remained significant after correction for multiple testing. We infer that VDR haplotypes might influence the risk of HIV-1 acquisition.

References

Aug 14, 2002·International Journal of Hygiene and Environmental Health·Fabian TermorshuizenHenk Van Loveren
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Jan 5, 2005·The Journal of Infectious Diseases·Richard A KaslowJames Jianming Tang
Jun 15, 2006·Nutrition Reviews·Eduardo Villamor
Jun 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jan EhrchenAndreas Lengeling
Jun 9, 2007·Journal of Molecular Endocrinology·Julián NevadoAna Aranda

❮ Previous
Next ❯

Citations

Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sule AslanFerda Ozkinay
Jun 23, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D YoussefA N Peiris
Apr 22, 2010·Biogerontology·Marina LaplanaJoan Fibla
Aug 7, 2012·AIDS Patient Care and STDs·Allen T Griffin, Forest W Arnold
Nov 16, 2011·Pharmacogenetics and Genomics·Inna G OvsyannikovaGregory A Poland
Jun 6, 2013·The Pediatric Infectious Disease Journal·Amaran MoodleyStephen A Spector
Dec 23, 2008·AIDS·Masaaki MiyazawaUNKNOWN ESN Study Group
Oct 2, 2009·Journal of Gastroenterology and Hepatology·Mohammad Kazemi ArababadiMohammad Ebrahim Rezvani
Sep 22, 2011·BMC Systems Biology·Luigi BuonaguroFrancesco M Marincola
May 20, 2009·Pharmacogenomics·Gregory A PolandRobert M Jacobson
Sep 29, 2011·Tuberculosis·S RaghavanP Selvaraj
Oct 30, 2010·Journal of the American Medical Directors Association·William B Grant, Alan N Peiris
Jan 5, 2011·Immunological Reviews·Luigi Buonaguro, Bali Pulendran
May 25, 2011·Geriatrics & Gerontology International·Dima A YoussefAlan N Peiris
Aug 8, 2014·Scientifica·Anna K CoussensRobert J Wilkinson
Jan 20, 2012·Dermato-endocrinology·Dima A YoussefAlan N Peiris
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rocio HerreroAntonio Caruz
Jan 2, 2014·Therapeutic Advances in Gastroenterology·Wallace J WangMoshe Rubin
Jan 8, 2019·Reviews in Medical Virology·Majid Teymoori-RadSayed Mahdi Marashi
Feb 23, 2020·Expert Review of Clinical Immunology·Claudio FeniziaMara Biasin
Mar 30, 2018·Frontiers in Immunology·María Ángeles Jiménez-SousaSalvador Resino
Dec 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela SironiMario Clerici
Jul 2, 2019·Genetics and Molecular Biology·Ronaldo Celerino da SilvaJaqueline de Azevêdo Silva
Mar 8, 2019·Journal of Clinical Medicine·María A Jiménez-SousaSalvador Resino
Jun 12, 2021·Expert Review of Anti-infective Therapy·Sadaf Jamal GilaniImran Kazmi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.