Vitamin D receptor gene polymorphism is associated with urinary calcium excretion but not with bone mineral density in postmenopausal women

Journal of Endocrinological Investigation
Boonsong OngphiphadhanakulG Puavilai

Abstract

Polymorphism of vitamin D receptor (VDR) gene has been found to be associated with serum osteocalcin (OC) levels and bone mineral density (BMD) in Caucasian identical twins and unrelated postmenopausal women. Being ethnically different and living in a geographic area with adequate vitamin D status due to abundant sunshine exposure, it is unclear whether VDR gene polymorphism will affect bone mass in Thai population. In the present study, we investigated the association between VDR gene polymorphism and bone metabolism in Thai postmenopausal women. Subjects consisted of 84 postmenopausal women. Bsm I, Taq I and Apa I polymorphisms of VDR gene were determined by PCR-RFLP. B, T and A represent the absence of the corresponding restriction sites while b, t and a indicate the presence of the restriction sites. Data were expressed as mean +/- SE. Sixty-six subjects (78.6%) had bb genotype while 18 (21.4%) had Bb genotype. None of the subjects was found to have BB genotype. Taq I restriction site was in linkage disequilibrium to the Bsm I site. For Apa I polymorphism, 33 (39.3%), 42 (50.0%) and 9 (10.7%) of the subjects had aa, Aa and AA genotypes, respectively. There was no significant difference in serum intact OC levels and BMD at v...Continue Reading

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Citations

Apr 16, 2010·Nutrition·La-or ChailurkitRajata Rajatanavin
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ammarin ThakkinstianJohn Attia
Apr 9, 2008·Journal of the Medical Association of Thailand = Chotmaihet Thangphaet·Chatlert PongchaiyakulNimit Taechakraichana
Jul 25, 2000·European Journal of Clinical Investigation·B L LangdahlE F Eriksen
Jun 7, 2002·Endocrine Reviews·Munro PeacockTatiana Foroud
May 3, 2003·The British Journal of Nutrition·Silvia ValtueñaFrancesco Branca

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