Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Lipids in Health and Disease
Elham KazemianSayed Hossein Davoodi

Abstract

We investigated whether vitamin D receptor (VDR) polymorphisms are associated with circulating metabolic biomarkers and anthropometric measures changes in breast cancer survivors supplemented with vitamin D3. One hundred sixty-eight breast cancer survivors admitted to Shohaday-e-Tajrish hospital received 4000 IU of daily vitamin D3 supplements for 12 weeks. Anthropometric measurements as well dietary, physical activity and plasma metabolic biomarkers assessments were performed before and after intervention. VDR polymorphisms were considered as the main exposures. Multivariate multiple linear regression analyses were used to determine the association between the VDR single-nucleotide polymorphisms (SNPs) and changes in metabolic and anthropometric measures in response to vitamin D3 supplementation. One hundred twenty-five (85%) women had insufficient and inadequate levels of plasma 25-hydroxy vitamin D (25(OH)D) at baseline. Compared to the AA genotype of the ApaI, the aa category showed greater increase in muscle mass [71.3(10.7131.9)] and higher decrease in LDL-C [- 17.9(- 33.6, - 2.3)] levels after adjustment for potential confounders. In addition, the heterozygous genotype (Bb) of the BsmI VDR was associated with higher incr...Continue Reading

References

Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S KumanyikaUNKNOWN Public Health Approaches to the Prevention of Obesity (PHAPO) Working Group of the International Obesity Task Force (IOTF)
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Oct 28, 2004·Journal of Endocrinological Investigation·A A Mirsaeid GhaziF Azizi
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAnne E de Papp
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth R Bertone-JohnsonSusan E Hankinson
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 30, 2008·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Alicja FilusMarek Medraś
Oct 30, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Urszula Tworowska-BardzińskaAndrzej Milewicz
Mar 27, 2009·The American Journal of Clinical Nutrition·Armin ZittermannReiner Koerfer
Dec 4, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H A Bischoff-FerrariW C Willett
Dec 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T DorjgochooX O Shu
Oct 11, 2012·The British Journal of Nutrition·Cherlyn DingChen Bing
Nov 15, 2012·JAMA : the Journal of the American Medical Association·Gregory P LevinBryan Kestenbaum
Feb 6, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K S VimaleswaranE Hyppönen
Feb 18, 2014·Current Nutrition Reports·Maria Azrad, Wendy Demark-Wahnefried
Feb 22, 2014·Molecular Diagnosis & Therapy·Antonio J Berlanga-Taylor, Julian C Knight
Mar 14, 2014·The American Journal of Clinical Nutrition·Caitlin MasonAnne McTiernan
Nov 2, 2014·The Proceedings of the Nutrition Society·L Kirsty Pourshahidi
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Paloma Muñoz-AguirreJorge Salmerón
Feb 18, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Pereira-SantosD B Santos
Mar 5, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Davide SerranoSara Gandini
Mar 22, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Tina JafariGholamreza Askari
Apr 22, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Amena SadiyaSalah Abusnana
Oct 3, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Donald G MatthewsJoEllen Welsh
Feb 18, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Norah AlmesriHayder Ahmed Giha
Aug 16, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Manal A Abbas
Oct 11, 2016·The Journal of Nutritional Biochemistry·Nathália GraveJúlia Pasqualini Genro

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Methods Mentioned

BETA
genotyping
ELISA
X-Ray

Software Mentioned

. stats
R
Stat
R package
Stata14
R Development Core Team
R package “ HardyWeinberg ”
haplo
Global

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