PMID: 9556140Apr 29, 1998Paper

Vitamin D receptor gene polymorphisms and peak bone mass in southern Chinese women

Bone
A W KungK S Lau

Abstract

Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40 years, and correlated their peak bone mass with the VDR genotypes. In comparison to Western populations, the B allele of the BsmI site is only found in 5% of the Chinese population. The BBAAtt genotype is virtually nonexistent in Chinese people. Except for the slightly higher BMD values at the midlateral L-3 vertebra (13.8%, p = 0.045) and at the Ward's triangle (13.3%, p = 0.08) in the bb subjects, no difference could be detected at other sites between the Bb and bb subjects. The same findings were observed when comparing the Tt to tt subjects. Analysis of the VDR genotype revealed that subjects with BbAaTt and BbAATt haplotypes had the lowest peak bone mass. Their L2-4 lumbar spine, midlateral L-3 vertebra, and Ward's triangle BMD was 1.04, 0.90, and 0.75 standard deviation (SD), respectively, lower than the bbAATT counterparts, but none of the comparisons were statistically significant. However, with the low fr...Continue Reading

References

Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K K PunT Loh
Oct 1, 1994·Lancet·H MelhusS Ljunghall
Nov 1, 1994·The Journal of Clinical Investigation·F G HustmyerJ Christian
Jan 20, 1994·Nature·N A MorrisonJ A Eisman

❮ Previous
Next ❯

Citations

Jul 19, 2006·Human Genetics·Ching-Lung CheungAnnie W C Kung
Apr 20, 2006·Journal of Bone and Mineral Metabolism·Helen H L LauAnnie W C Kung
Feb 26, 2009·Journal of Bone and Mineral Metabolism·Heidi H Y NgaiAnnie W C Kung
Aug 10, 2007·Journal of Human Genetics·Qing-Yang Huang, Annie W C Kung
Jan 5, 2007·Journal of Epidemiology·Akie KanekoTakehito Takano
Mar 19, 2011·Climacteric : the Journal of the International Menopause Society·T YoldemirM Erenus
Oct 13, 2017·International Journal of Epidemiology·Ching-Lung CheungAnnie W C Kung
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Ching-Lung CheungAnnie W C Kung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
E M LauJ A Critchley
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
P GarneroP D Delmas
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
J M ZmudaR E Ferrell
© 2022 Meta ULC. All rights reserved