Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

Arthritis Research & Therapy
Svetlana SolovievaPäivi Leino-Arjas

Abstract

We examined whether polymorphisms of the vitamin D receptor (VDR) gene was associated with individual risk of hand osteoarthritis (OA). Radiographs of both hands of 295 dentists and of 248 teachers were examined and classified for the presence of OA using reference images. The VDR ApaI and TaqI genotypes were determined by PCR-based methods. No association was observed between the VDR polymorphisms and the odds of overall hand OA. However, the carriers of the VDR t allele or At haplotype were at almost half the odds of symmetrical hand OA (odds ratio [OR] = 0.60, 95% confidence interval [CI] = 0.38-0.94 and OR = 0.59, 95% CI = 0.38-0.93, respectively) compared with the carriers of the T allele and of the non-At haplotype, respectively. Increased odds of this disease, on the contrary, was observed for women with two copies of the VDR a allele (OR = 1.93, 95% CI = 1.99-3.70) compared with women with the AA genotype. Conversely, the VDR a allele carriage was associated with a tendency of lowered odds of osteophyte (OR = 0.51, 95% CI = 0.25-1.03). When the genotype data were used to construct haplotypes, the VDR AaTt joint genotype appeared to pose a remarkably lower odds (OR = 0.26, 95% CI = 0.08-0.91) of osteophyte compared with ...Continue Reading

References

Mar 1, 1978·Arthritis and Rheumatism·N M HadlerN Moskovitz
Jan 1, 1991·Calcified Tissue International·R P Heaney
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A KrallB Dawson-Hughes
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsJ A Eisman
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Apr 1, 1994·Annals of the Rheumatic Diseases·D HartC Cooper
Apr 13, 1996·BMJ : British Medical Journal·T D SpectorD Hart
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L M SalamoneJ A Cauley
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·T CarlingG Akerström
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D P KielM F Holick
Jul 15, 1997·The Journal of Clinical Investigation·A G UitterlindenH A Pols
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M ZmudaR E Ferrell
Feb 12, 1998·Calcified Tissue International·L GennariM L Brandi
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A RubinD E Cole
Oct 18, 2000·Annals of Internal Medicine·D T FelsonJ F Fries
Jan 13, 2001·Osteoarthritis and Cartilage·D J Hart, T D Spector
Feb 24, 2001·Epidemiologic Reviews·J M ZmudaR E Ferrell
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A BrownJ A Eisman
Oct 18, 2001·Journal of the American College of Nutrition·M B Zemel
Oct 18, 2001·Current Opinion in Rheumatology·L Sharma
Oct 18, 2001·Current Opinion in Rheumatology·M Sowers
Feb 14, 2002·Rheumatic Diseases Clinics of North America·John Loughlin
Apr 16, 2002·Arthritis and Rheumatism·S DemissieD T Felson
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Jan 26, 1952·British Medical Journal·J H KELLGREN, R MOORE
Apr 2, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ammarin ThakkinstianJohn Attia
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·André G UitterlindenHuibert A P Pols

❮ Previous
Next ❯

Citations

Jun 6, 2009·Arthritis Research & Therapy·Jacqueline E Oliver, Alan J Silman
Aug 1, 2015·International Journal of Endocrinology·Thomas Mabey, Sittisak Honsawek
Mar 8, 2014·Experimental Biology and Medicine·Huifang LiuChengqi He
Dec 17, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Young Ho LeeGwan Gyu Song
May 15, 2013·Nature Reviews. Rheumatology·Bo Abrahamsen, Nicholas C Harvey
Jul 1, 2007·Expert Review of Clinical Immunology·Charlene J Williams
Nov 5, 2020·Rheumatology·Hui-Min LiCai-Liang Shen
Jan 29, 2021·Arthritis Research & Therapy·Xiaoxia HaoTao Xu
Aug 24, 2021·Osteoarthritis and Cartilage·X-H YuS-F Lei

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
PCR
genotyping

Software Mentioned

PHASE
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Volodymyr DvornykHong-Wen Deng
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Oğuz SöylemezoğluNecla Buyan
© 2021 Meta ULC. All rights reserved