Vitamin-D receptor gene polymorphisms (TaqI and ApaI) and circulating osteocalcin in type 2 diabetic patients and healthy subjects

Endokrynologia Polska
Edgar-Alfonso Rivera-LeonSergio Sanchez-Enriquez

Abstract

Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator of glucose metabolism in mice. Moreover, OC level is decreased in patients with type 2 diabetes (T2D). Although inversely correlated with serum glucose insulin and glycated haemoglobin, it is unclear whether OC reduction is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. In this study we analysed the association between TaqI and ApaI VDR gene polymorphisms and OC serum concentration in T2D subjects. Patients underwent clinical and nutritional assessment. Genomic DNA was extracted from leucocytes using a standard salting-out procedure. The polymorphisms were genotyped by PCR-RFLP method. ELISA was used to measure OC and insulin concentrations. Association between TT genotype of TaqI polymorphism and low levels of OC was observed only in the population with overweight and obesity. No association between TaqI and ApaI polymorphisms and T2D was observed (p > 0.05). Furthermore, in T2D subj...Continue Reading

Citations

Mar 5, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Sule YesilGurses Sahin
Aug 22, 2017·Lipids in Health and Disease·Fei-Fei HanLi-Hong Liu
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Buthaina E AlathariKarani Santhanakrishnan Vimaleswaran
Apr 18, 2021·BMC Cardiovascular Disorders·Damir RaljevićSandra Kraljević Pavelić

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