Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis

Scientific Reports
Javier Rodríguez-CarrioAna Suárez

Abstract

Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D. Our aim was to evaluate the impact of vitamin D-related polymorphisms and DHCR7 levels in the association between vitamin D deficiency and altered lipid profile in rheumatoid arthritis (RA). Serum 25(OH)-vitamin D, DHCR7 levels and vitamin D-related polymorphisms (VDR-rs2228570, CYP27A1-rs933994, CYP2R1-rs10741657 and DHCR7-rs12785878) were analyzed in 211 RA patients,94 controls and in a prospective cohort of 13 RA patients undergoing TNFα-blockade. Vitamin D was decreased in RA (p < 0.001), correlated to HDL-cholesterol (r = 0.217, p < 0.001) and total-/HDL-cholesterol ratio (r = -0.227, p = 0.004). These correlations were restricted to the VDR-rs2228570 status. Vitamin D deficiency was associated with lower HDL-cholesterol (p = 0.028), higher tender (p = 0.005) and swollen (p = 0.002) joint counts, higher DAS28 (p = 0.018) and HAQ (p = 0.024) in AG/AA-patients but not in their GG-counterparts. The associations among DHCR7, vitamin D and lipid profile followed a seasonal pattern, decreased DHCR7 (p = 0.008) and vitamin D (p < 0.001) and increased total-cholesterol (p = 0.025) being found in winter/s...Continue Reading

References

Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·G C van den BemdJ P van Leeuwen
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Apr 28, 2004·Archives of Internal Medicine·Ira S OckeneJames R Hebert
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Jing-Huan WangPentti Tuohimaa
Dec 1, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Yan-Ru LouPentti Tuohimaa
Feb 26, 2010·Kidney International·Annemieke VerstuyfChantal Mathieu
Mar 20, 2010·Rheumatology International·Ayşe Dicle TurhanoğluCahit Ozer
Sep 9, 2010·European Journal of Clinical Nutrition·R JordeG Grimnes
Jun 7, 2011·Progress in Lipid Research·Rolf Jorde, Guri Grimnes
Jun 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Mohamed B ElaminVictor M Montori
Aug 29, 2012·Dermato-endocrinology·Michael F Holick
Feb 2, 2013·Current Opinion in Rheumatology·Paul GatenbyAshwin Swaminathan
Jun 19, 2013·Nature Reviews. Rheumatology·Jamie RobertsonNaveed Sattar
Oct 15, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Doris M HummelEnikő Kállay
Dec 17, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Ling Zou, Todd D Porter
Aug 15, 2015·Arthritis Research & Therapy·Ana Urruticoechea-AranaUNKNOWN CARMA Project Collaborative Group
Nov 5, 2016·Progress in Lipid Research·Anika V PrabhuAndrew J Brown
May 4, 2017·Current Opinion in Rheumatology·Nicola L BragazziYehuda Shoenfeld
Nov 9, 2017·Clinical Rheumatology·Elena NikiphorouTuulikki Sokka

❮ Previous
Next ❯

Citations

Dec 23, 2020·International Journal of Molecular Sciences·Adolfo I Ruiz-BallesterosUlises de la Cruz-Mosso
May 3, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Spyridon N KarrasKalliopi Kotsa

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

GraphPad Prism
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.