Vitamin D receptor polymorphisms correlate to parathyroid cell function in primary hyperparathyroidism

The Journal of Clinical Endocrinology and Metabolism
T CarlingG Akerström

Abstract

Calcitriol acts via its receptor (VDR) and inhibits PTH secretion and parathyroid cell proliferation. Increased prevalence of the polymorphic VDR alleles b, a, and T has been demonstrated in sporadic primary hyperparathyroidism. Sixty-two patients with primary hyperparathyroidism due to parathyroid adenoma (mean age, 69.5 +/- 1.4 yr) were genotyped for these VDR polymorphisms. Dispersed cells of the adenomas were exposed to increasing concentrations of extracellular Ca2+ and analyzed for PTH release and cytoplasmic Ca2+ concentrations. Ca2+-mediated PTH inhibition exhibited higher ED50 and less suppression in the cells of patients who were homozygous for the b, a, and T alleles (P < 0.05-0.10). When analyzing haplotypes, the patients with baT demonstrated a ED50 of 1.81 +/- 0.15 vs. 1.29 +/- 0.10 for BAt (P < 0.05). As VDR alleles were unrelated to parathyroid intracellular Ca2+, influences of polymorphic VDR alleles on PTH secretion seem to involve mechanisms other than the Ca2+-sensing protein of the parathyroid cell surface.

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Citations

Mar 2, 2006·Arthritis Research & Therapy·Svetlana SolovievaPäivi Leino-Arjas
Nov 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ibrahim AcikbasHuseyin Bagci
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez
Apr 4, 2015·BioMed Research International·Muzaffer IlhanErtugrul Tasan
Sep 6, 2000·Clinical Endocrinology·D Sudhaker RaoA M Parfitt

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