Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view

Canadian Journal of Physiology and Pharmacology
C Carlberg, Ferdinand Molnár

Abstract

Vitamin D3 is one of the few natural compounds that has, via its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the transcription factor vitamin D receptor (VDR), a direct effect on gene regulation. For efficiently applying the therapeutic and disease-preventing potential of 1,25(OH)2D3 and its synthetic analogs, the key steps in vitamin D signaling need to be understood. These are the different types of molecular interactions with the VDR, such as (i) the complex formation of VDR with genomic DNA, (ii) the interaction of VDR with its partner transcription factors, (iii) the binding of 1,25(OH)2D3 or its synthetic analogs within the ligand-binding pocket of the VDR, and (iv) the resulting conformational change on the surface of the VDR leading to a change of the protein-protein interaction profile of the receptor with other proteins. This review will present the latest genome-wide insight into vitamin D signaling, and will discuss its therapeutic implications.

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Citations

Jun 11, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sabine SeuterCarsten Carlberg
Oct 21, 2016·Biochimica Et Biophysica Acta·Antonio NemeCarsten Carlberg
Oct 16, 2018·Expert Review of Endocrinology & Metabolism·Barbara J Boucher
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Mar 28, 2019·Oxidative Medicine and Cellular Longevity·Xiuzhen ZhaoYing Zhang
Oct 19, 2019·International Journal of Molecular Sciences·Smriti Murali Krishna
Sep 12, 2020·International Journal of Molecular Sciences·Federica SaponaroRiccardo Zucchi
Mar 28, 2019·Journal of Medicinal Chemistry·Miguel A MaestroCarsten Carlberg

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