Vitamin D receptor signaling is required for heart development in zebrafish embryo

Biochemical and Biophysical Research Communications
Hye-Joo Kwon

Abstract

Vitamin D has been found to be associated with cardiovascular diseases. However, the role of vitamin D in heart development during embryonic period is largely unknown. Vitamin D induces its genomic effects through its nuclear receptor, the vitamin D receptor (VDR). The present study investigated the role of VDR on heart development by antisense-mediated knockdown approaches in zebrafish model system. In zebrafish embryos, two distinct VDR genes (vdra and vdrb) have been identified. Knockdown of vdra has little effect on heart development, whereas disrupting vdrb gene causes various cardiac phenotypes, characterized by pericardial edema, slower heart rate and laterality defects. Depletion of both vdra and vdrb (vdra/b) produce additive, but not synergistic effects. To determine whether atrioventricular (AV) cardiomyocytes are properly organized in these embryos, the expression of bmp4, which marks the developing AV boundary at 48 h post-fertilization, was examined. Notably, vdra/b-deficient embryos display ectopic expression of bmp4 towards the ventricle or throughout atrial and ventricular chambers. Taken together, these results suggest that VDR signaling plays an essential role in heart development.

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Citations

Aug 17, 2016·Biochemical and Biophysical Research Communications·Hye-Joo Kwon
Nov 16, 2016·International Journal of Molecular Sciences·Jie YangFang Zheng
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nasim JamaliNader Sheibani
Sep 25, 2019·Cold Spring Harbor Perspectives in Biology·Jacinta Isabelle Kalisch-SmithDuncan Burnaby Sparrow
Nov 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christoph Englert
Nov 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amie L T RomneyJason E Podrabsky
Jun 27, 2019·Journal of Developmental Biology·Hye-Joo Kwon

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