Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men

Steroids
Pascalin RoyClaudia Gagnon

Abstract

Both vitamin D deficiency and inflammation have been associated with insulin resistance and type 2 diabetes risk. In vitro vitamin D treatment of subcutaneous (SC) adipose tissue (AT) may reduce inflammation, but data are conflicting. To evaluate the effects of vitamin D (25(OH)D3 and 1,25(OH)2D3) on the secretion of inflammatory cytokines (TNF-α and IL-6) in omental (OM) and SC human AT and to explore factors that could correlate with the individual response to vitamin D including age, smoking status, BMI, comorbidities, medication, HbA1c, apolipoprotein B, serum 25-hydroxyvitamin D and high sensitivity C-reactive protein. 7 men and 8 women with severe obesity undergoing bariatric surgery. Fresh OM and SC AT explants sampled during surgery (n=15) were incubated for 24h in a control, 25(OH)D3 (150 nM) or 1,25(OH)2D3 (1 nM) medium. Lipopolysaccharide (LPS) (10 ng/ml) was added for another 24h. Change in TNF-α and IL-6 levels in collected media after vitamin D treatment (ELISA). Mean age and BMI of the patients were 46.4±10.9 years and 48.8±7.5 kg/m(2), respectively. Eleven patients had type 2 diabetes. 25(OH)D3 and 1,25(OH)2D3 reduced the LPS-induced increases in cytokine levels in OM AT of women but not in men. No effect was ob...Continue Reading

References

Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M T EscaleiraM M Brentani
Apr 1, 1993·European Journal of Clinical Investigation·B RichelsenJ D Børglum
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Feb 15, 2007·Obesity·Xiaocun Sun, Michael B Zemel
Mar 24, 2007·Metabolism: Clinical and Experimental·Ariane BoivinAndré Tchernof
Sep 18, 2007·The Journal of Nutritional Biochemistry·Xiaocun Sun, Michael B Zemel
May 23, 2008·Epidemiology·Paul KnektAntti Reunanen
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Judith Aron-WisnewskyKarine Clément
Aug 24, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L S Greene-FinestoneUNKNOWN CaMos Research Group
Sep 2, 2010·Diabetes Care·Anastassios G PittasFrank B Hu
Jun 28, 2011·European Journal of Nutrition·Silvia Lorente-CebriánMikael Rydén
Jul 28, 2011·European Journal of Clinical Nutrition·L K JohnsonJ Hjelmesæth
Feb 22, 2012·Diabetes/metabolism Research and Reviews·Sakineh Shab-BidarA'azam Gharavi
Apr 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D GaoC Bing
Jul 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shivaprakash J MuttKarl-Heinz Herzig
Jul 26, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L WambergS B Pedersen
Oct 4, 2012·Diabetes Care·Mayer B DavidsonTheodore C Friedman
Oct 11, 2012·The British Journal of Nutrition·Cherlyn DingChen Bing
Oct 16, 2012·Molecular Nutrition & Food Research·Julie MarcotorchinoJean-François Landrier
Dec 5, 2012·Annals of Nutrition & Metabolism·T MezzaA Giaccari
Jan 17, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L WambergS B Pedersen
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sedigheh SoheilykhahAhmad Shojaoddiny-Ardekani
Feb 15, 2013·The American Journal of Clinical Nutrition·Anthony M BelenchiaCatherine A Peterson
Mar 14, 2013·Nutrients·Andrea M Caricilli, Mario J A Saad
Nov 5, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Amy E RiekCarlos Bernal-Mizrachi
May 9, 2014·Frontiers in Microbiology·Isabel Moreno-IndiasMaría Isabel Queipo-Ortuño

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Citations

Apr 10, 2019·Nutrients·Izabela Szymczak-Pajor, Agnieszka Śliwińska
Sep 17, 2020·International Journal of Molecular Sciences·Izabela Szymczak-PajorAgnieszka Śliwińska
Mar 19, 2019·Frontiers in Endocrinology·Irina ZakharovaAndrey Lebedev

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