PMID: 18187872Jan 12, 2008Paper

Vitamin D status affects osteopenia in postmenopausal patients with primary hyperparathyroidism

Endocrine Journal
Yoshifumi InoueK Chihara

Abstract

Controversy still exists about whether vitamin D status is related to the severity of primary hyperparathyroidism (pHPT), although vitamin D insufficiency is frequent in pHPT. The present study was therefore performed to examine the relationships between vitamin D status and various parameters in 30 postmenopausal pHPT patients. BMD values were measured by dual-energy x-ray absorptiometry at the lumbar spine (L(2-4)), femoral neck (FN) and distal one third of the radius (Rad 1/3). Serum levels of 25 hydroxy-vitamin D(3) [25(OH)D] and 1,25-dihydroxy vitamin D(3) [1,25(OH) (2)D(3)] were 15.8 +/- 3.5 microg/l and 69.3 +/- 33.3 ng/l in pHPT patients, respectively. Serum levels of calcium and PTH seemed to be negatively correlated to serum 25(OH)D levels, although the differences were not significant. However, when subjects with the highest serum PTH levels (PTH>1000 pg/ml) were excluded from the analysis, the correlation was significant between serum 25(OH)D levels and PTH, indicating that vitamin D status affects the severity of pHPT when severe cases were excluded. In addition, serum levels of 1,25(OH)(2)D(3) were significantly and negatively correlated to serum 25(OH)D levels. On the other hand, serum levels of 25(OH)D were sign...Continue Reading

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Feb 3, 2011·Calcified Tissue International·Mika YamauchiToshitsugu Sugimoto
Jun 9, 2012·Annales d'endocrinologie·Jean-Claude SouberbielleCatherine Cormier
Apr 20, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Jean-Claude SouberbielleCatherine Cormier
Aug 30, 2013·International Journal of Endocrinology·Erik NordenströmMartin Almquist
Jun 17, 2015·The Journal of Clinical Endocrinology and Metabolism·Marcella D WalkerShonni J Silverberg
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May 29, 2018·Archives of Osteoporosis·Vivek DixitDinesh Kumar Dhanwal
Jul 13, 2021·Curēus·Kunal DholakiaNarasimhan Ragavan

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