Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease

Pediatric Obesity
P S GibsonJ B Moore

Abstract

Vitamin D deficiency has been associated with non-alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown. The objectives of this study were to determine in UK children with biopsy-proven NAFLD (i) their vitamin D status throughout a 12-month period and (ii) interactions between key vitamin D-related genetic variants (nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7, vitamin D receptor, group-specific component, CYP2R1) and disease severity. In 103 paediatric patients with NAFLD, serum 25-hydroxyvitamin D (25OHD) levels and genotypes were determined contemporaneously to liver biopsy and examined in relation to NAFLD activity score and fibrosis stage. Only 19.2% of children had adequate vitamin D status; most had mean 25OHD levels considered deficient (<25 nmol·L-1 , 25.5%) or insufficient (<50 nmol·L-1 , 55.3%). Patients had significantly lower 25OHD levels in winter months (95% CI: 22.7-31.2 nmol·L-1 ) when compared with spring (30.5-42.1 nmol·L-1 ; P = 0.0089), summer (36.3-47.2 nmol·L-1 ; P < 0.0001) and autumn (34.2-47.5 nmol·L-1 ; P = 0.0003). Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reducta...Continue Reading

References

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Citations

Sep 1, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Jun Sun
Oct 8, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Zixuan ZhangJ Bernadette Moore
Aug 25, 2019·European Journal of Clinical Nutrition·Toshifumi YodoshiMarialena Mouzaki
Jan 1, 2018·Nuclear Receptor Research·Danika BakkeJun Sun
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili

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Methods Mentioned

BETA
biopsy
biopsies
Assay
genotyping

Software Mentioned

HAPmap
Prism
GraphPad

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