Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis

Journal of Neuroimmunology
Egil RøsjøTrygve Holmøy

Abstract

To explore if vitamin D modulates interferon-β1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon-β1a treatment effects.

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Citations

Jan 23, 2016·Expert Review of Neurotherapeutics·Trygve Holmøy, Øivind Torkildsen
Oct 20, 2015·Neurodegenerative Disease Management·Robyn M LucasPrue H Hart
Jan 8, 2017·Journal of Pharmaceutical and Biomedical Analysis·Diego Luque-Córdoba, María D Luque de Castro
Oct 15, 2018·Acta Neurologica Scandinavica·Trygve HolmøyMargitta T Kampman
Mar 22, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S WergelandØ Torkildsen
May 20, 2020·Frontiers in Neurology·Egil RøsjøØivind Torkildsen
Jun 4, 2015·Acta Neurologica Scandinavica·T HolmøyK-M Myhr
Dec 22, 2020·Frontiers in Immunology·Niccolò BianchiSilvia Monticelli
Aug 14, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L B Tlapshokova, A R Zikhova

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