Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Yuhui ZhangJie Dong

Abstract

Vitamin D deficiency is highly prevalent in patients on dialysis. Although vitamin D deficiency is closely associated with cardiovascular disease (CVD) and high mortality in the general population, the relationship between serum 25-hydroxyvitamin D [25(OH)D] and all-cause and cardiovascular mortality in dialysis patients is uncertain. We aim to explore the relationship between serum 25(OH)D levels and all-cause and cardiovascular mortality in dialysis patients. This is a systematic review and meta-analysis of clinical studies among patients receiving maintenance dialysis. We did a systematic literature search in PubMed and Embase to identify studies reporting the relationship between serum 25(OH)D levels and all-cause and cardiovascular mortality in patients on dialysis. The search was last updated on 10 February 2017. The study included 18 moderate to high-quality cohort studies with an overall sample of 14 154 patients on dialysis. The relative risk of all-cause mortality per 10 ng/mL increase in serum 25(OH)D level was 0.78 [95% confidence interval (CI) 0.71-0.86], although there was marked heterogeneity (I2=96%, P < 0.01) that was partly explained by differences in CVD prevalence, baseline parathyroid hormone level and dial...Continue Reading

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Citations

Sep 7, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Mario Fernández-RuizJosé María Aguado
Jul 31, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guobin SuCecilia Stålsby Lundborg
Apr 21, 2019·Drugs·Matthew Hulse, Mitchell H Rosner
Mar 12, 2021·Hemodialysis International·Barbara Perez Vogt, Jacqueline Costa Teixeira Caramori
Apr 4, 2021·International Journal of Molecular Sciences·Armin ZittermannStefan Pilz
Jul 1, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Shang-Yi LinYen-Hsu Chen
Aug 28, 2021·Nutrients·María Dolores Arenas JimenezJulio Pascual

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