Vitamin D status and the effects of oral vitamin D treatment in children with vitiligo: A prospective study

Clinical Nutrition ESPEN
Gülay KaragüzelAyşenur Ökten

Abstract

Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study. Size of the vitiligo representative area was estimated using the point counting method and blood samples were obtained at the beginning and month six. By the end of the study, all patients treated with topical tacrolimus for six months and the patients who were vitamin D deficient (n = 14) had been on combination treatment of oral vitamin D and topical tacrolimus. A dose of 1500 IU/day vitamin D was given if the serum 25(OH)D levels <20 ng/ml and 3000 IU/day was given if the levels <10 ng/ml for six months. Serum 25(OH)D levels were measured by high-performance liquid chromatography. Serum 25(OH)D levels of patients and controls were not significantly different (p > 0.05)...Continue Reading

Citations

Aug 24, 2017·Dermatologic Therapy·Nooshin BagheraniTorello Lotti
Aug 16, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Roberta ColucciSilvia Moretti
Dec 19, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Anastasia ShakhbazovaRaja K Sivamani
Jul 20, 2019·Autoimmunity Reviews·Giuseppe MurdacaSebastiano Gangemi

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