Vitamin D status and the risk of type 2 diabetes: The Melbourne Collaborative Cohort Study

Diabetes Research and Clinical Practice
Alicia K HeathDallas R English

Abstract

Inverse associations between vitamin D status and risk of type 2 diabetes observed in epidemiological studies could be biased by confounding and reverse causality. We investigated the prospective association between vitamin D status and type 2 diabetes and the possible role of reverse causality. We conducted a case-cohort study within the Melbourne Collaborative Cohort Study (MCCS), including a random sample of 628 participants who developed diabetes and a sex-stratified random sample of the cohort (n = 1884). Concentration of 25-hydroxyvitamin D (25(OH)D) was measured using liquid chromatography-tandem mass spectrometry in samples collected at recruitment. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of type 2 diabetes for quartiles of 25(OH)D relative to the lowest quartile and per 25 nmol/L increase in 25(OH)D, adjusting for confounding variables. The ORs for the highest versus lowest 25(OH)D quartile and per 25 nmol/L increase in 25(OH)D were 0.60 (95% CI: 0.44, 0.81) and 0.76 (95% CI: 0.63, 0.92; p = 0.004), respectively. In participants who reported being in good/very good/excellent health approximately four years after recruitment, ORs for the highest versus l...Continue Reading

Citations

Feb 15, 2020·Nutrición hospitalaria·Hillary Kimberly Osorio LandaElizabet Sánchez Landa
Mar 18, 2020·Reviews in Endocrine & Metabolic Disorders·A GiustinaJ P Bilezikian
Mar 20, 2019·Nutrients·Araceli Muñoz-GarachManuel Muñoz-Torres
Oct 18, 2020·Archives of Osteoporosis·Louise Forsyth WilsonJenny Doust
Mar 8, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alicia K HeathDallas R English
Feb 3, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Alicia K HeathElizabeth J Williamson

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