Vitamin D Status in Different Stages of Disease Severity in Dogs with Chronic Valvular Heart Disease

Journal of Veterinary Internal Medicine
T OsugaM Takiguchi

Abstract

In humans with heart disease, vitamin D deficiency is associated with disease progression and a poor prognosis. A recent study showed that serum 25-hydroxyvitamin D [25(OH)D] concentration, the hallmark of vitamin D status, was lower in dogs with heart failure than in normal dogs, and a low concentration was associated with poor outcome in dogs with heart failure. To elucidate the vitamin D status of dogs with chronic valvular heart disease (CVHD) at different stages of disease severity. Forty-three client-owned dogs with CVHD. In this cross-sectional study, dogs were divided into 3 groups (14 dogs in Stage B1, 17 dogs in Stage B2, and 12 dogs in Stage C/D) according to ACVIM guidelines. Dogs underwent clinical examination including echocardiography. Serum 25(OH)D concentrations were measured in each dog. Serum 25(OH)D concentration was significantly lower in Stage B2 (median, 33.2 nmol/L; range, 4.9-171.7 nmol/L) and C/D (13.1 nmol/L; 4.9-58.1 nmol/L) than in Stage B1 (52.5 nmol/L; 33.5-178.0 nmol/L) and was not significantly different between Stage B2 and Stage C/D. Among clinical variables, there were significant negative correlations between 25(OH)D concentration and both left atrial-to-aortic root ratio and left ventricula...Continue Reading

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Citations

Mar 24, 2016·The Journal of Small Animal Practice·R J Mellanby
May 14, 2016·Critical Reviews in Food Science and Nutrition·Nicole Weidner, Adronie Verbrugghe
Feb 2, 2017·Journal of Veterinary Internal Medicine·K NakamuraM Takiguchi
Sep 25, 2017·Journal of Veterinary Internal Medicine·N WeidnerA Verbrugghe
Dec 6, 2019·Journal of Animal Physiology and Animal Nutrition·Rafael V A ZafalonMarcio A Brunetto
Oct 23, 2019·Journal of Veterinary Emergency and Critical Care·Dava M CazzolliKen Lamb
Jun 20, 2020·Journal of Veterinary Internal Medicine·Wendy A WareMin Zhang
May 17, 2017·Journal of the American Veterinary Medical Association·Valerie J ParkerDennis J Chew
May 1, 2019·The Onderstepoort Journal of Veterinary Research·Eran DvirJohan P Schoeman
Sep 19, 2020·Metabolites·Emma A HurstRichard J Mellanby
Nov 13, 2020·Journal of Veterinary Internal Medicine·Dylan N ClementsRichard J Mellanby
Dec 9, 2020·Metabolites·Rafael Vessecchi Amorim ZafalonMarcio Antonio Brunetto
Mar 4, 2021·The Veterinary Clinics of North America. Small Animal Practice·Jonathan StockmanRonald Jan Corbee
Jul 30, 2021·The Journal of Small Animal Practice·K E ClarkeR J Mellanby

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