Vitamin D Supplementation for Childhood Asthma: A Systematic Review and Meta-Analysis

PloS One
Bruno D RiverinPatricia Li

Abstract

There is growing evidence that vitamin D plays a role in the pathogenesis of asthma but it is unclear whether supplementation during childhood may improve asthma outcomes. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of vitamin D supplementation as a treatment or adjunct treatment for asthma. We searched MEDLINE, Embase, CENTRAL, and CINAHL through July 2014. We included RCTs that evaluated vitamin D supplementation in children versus active control or placebo for asthma. One reviewer extracted data and one reviewer verified data accuracy. We qualitatively summarized the main results of efficacy and safety and meta-analyzed data on comparable outcomes across studies. We used GRADE for strength of evidence. Main planned outcomes measures were ED visits and hospitalizations. As secondary outcomes, we examined measures of asthma control, including frequency of asthma exacerbations, asthma symptom scores, measures of lung function, β2-agonist use and daily steroid use, adverse events and 25-hydroxyvitamin D levels. Eight RCTs (one parallel, one crossover design) comprising 573 children aged 3 to 18 years were included. One study (moderate-quality, n = 100) reported significantly ...Continue Reading

References

Feb 9, 2005·Annals of the New York Academy of Sciences·Elina HyppönenMarjo-Riitta Järvelinb
Dec 13, 2005·The Journal of Clinical Investigation·Emmanuel XystrakisCatherine M Hawrylowicz
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yingfang SongChanggui Wu
Jan 31, 2009·American Journal of Respiratory and Critical Care Medicine·John M BrehmAugusto A Litonjua
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Oct 13, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P MajakI Stelmach
Mar 12, 2010·The American Journal of Clinical Nutrition·Mitsuyoshi UrashimaHiroyuki Ida
Apr 13, 2010·The Journal of Allergy and Clinical Immunology·Daniel A SearingDonald Y M Leung
Jun 12, 2010·The Journal of Allergy and Clinical Immunology·John M BrehmUNKNOWN Childhood Asthma Management Program Research Group
Aug 31, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Manbir S Sandhu, Thomas B Casale
Nov 13, 2010·The European Respiratory Journal·I ChinellatoA L Boner
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt
Jan 21, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Feb 15, 2011·The Journal of Allergy and Clinical Immunology·Paweł MajakIwona Stelmach
Apr 16, 2011·Public Health Nutrition·A Catharine Ross
Jul 7, 2011·European Journal of Clinical Nutrition·J MitriA G Pittas
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 16, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Sep 21, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A A M van OeffelenA H Wijga
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Grace PaulJuan C Celedón
Dec 17, 2011·American Journal of Respiratory and Critical Care Medicine·Anthony N Gerber, E Rand Sutherland
Jan 24, 2012·Current Opinion in Allergy and Clinical Immunology·Augusto A Litonjua
Apr 4, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elena LewisThomas B Casale
Apr 26, 2012·Pulmonary Pharmacology & Therapeutics·Khanh vinh quoc Luong, Lan Thi Hoàng Nguyen
Jun 2, 2012·American Journal of Respiratory and Critical Care Medicine·John M BrehmJuan C Celedón
Jul 17, 2012·American Journal of Respiratory and Critical Care Medicine·Ann Chen WuUNKNOWN Childhood Asthma Management Program Research Group
Aug 29, 2012·Dermato-endocrinology·Sheena D BrownAnne M Fitzpatrick
Oct 17, 2012·Paediatric Respiratory Reviews·Atul GuptaSejal Saglani
Apr 19, 2013·The American Journal of Clinical Nutrition·Peter J GergenWilliam Busse
May 21, 2013·The Journal of Allergy and Clinical Immunology·Alexandra M NanzerCatherine M Hawrylowicz
May 29, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T AgrawalD K Agrawal
Nov 7, 2013·Indian Journal of Pediatrics·Madhu Yadav, Kundan Mittal
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Philippe AutierPatrick Mullie
Mar 29, 2014·Thorax·Sunita SharmaScott T Weiss

❮ Previous
Next ❯

Citations

Mar 16, 2016·American Journal of Respiratory and Critical Care Medicine·John W Upham, Peter D Sly
Mar 23, 2017·Immunology Letters·Peter A Tauber, Winfried F Pickl
Jan 13, 2017·Current Opinion in Allergy and Clinical Immunology·K A Lee-SarwarA A Litonjua
Nov 9, 2017·Nutrients·Laurent GuilleminaultLisa G Wood
Sep 7, 2016·The Cochrane Database of Systematic Reviews·Adrian R MartineauChris J Griffiths
Jun 16, 2018·Pediatric Pulmonology·Jessica A OmandJonathon L Maguire
Jan 25, 2019·Health Technology Assessment : HTA·Adrian R MartineauRichard L Hooper
May 18, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yoon Hee KimKyu-Earn Kim
Aug 3, 2018·BMJ Open·Abdullah Al-TaiarAnwar Al-Harbi
Feb 6, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Roberto AntonucciLuca Antonucci
Dec 19, 2016·Italian Journal of Pediatrics·Nasrin EsfandiarNiloofar Sedghi
Oct 27, 2018·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Gustavo Falbo Wandalsen, Dirceu Solé
May 28, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura Tenero, Attilio L Boner
Jun 9, 2016·Pediatric Pulmonology·Laura A LautenbacherDeepa Rastogi
Nov 30, 2019·Breathe·Isobel StoodleyLisa Wood
Aug 25, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Alana Alcântara GalvãoCamila Alexandrina Figueiredo
Sep 16, 2020·Pediatric Pulmonology·Brian P O'SullivanUNKNOWN IDeA States Pediatric Clinical Trials Network
Sep 11, 2020·The Lancet. Respiratory Medicine·Mariëlle W Pijnenburg, Louise Fleming
Mar 16, 2019·La Presse médicale·Awa BoussoCindy Barnig
May 1, 2021·International Journal of Molecular Sciences·Giuseppe MurdacaSebastiano Gangemi
Feb 6, 2017·Pediatrics·Emre BasatemurAlastair Sutcliffe

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Review Manager
Embase
Ovid

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Supichaya PojsupapJames Dayre McNally
Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine
Ana Luiza Cabrera MartimbiancoMaria Stella Peccin
© 2021 Meta ULC. All rights reserved