Vitamin D supplementation for children with cancer: A systematic review and consensus recommendations.

Cancer Medicine
Jenneke E van AtteveldSebastian J C M M Neggers

Abstract

Prevalent vitamin D deficiency (VDD) and low bone mineral density (BMD) have led to vitamin D supplementation for children with cancer, regardless vitamin D status. However, it remains unsettled whether this enhances bone strength. We sought to address this issue by carrying out a systematic review of the literature. We conducted a literature search using PubMed, Embase, and Cochrane databases. Studies including children up to 5 years after cancer therapy were assessed for the association between 25-hydroxyvitamin D (25OHD) levels and BMD Z-scores or fractures, and the effect of vitamin D supplementation on BMD or fractures. Evidence quality was assessed using the GRADE methodology. Nineteen studies (16 observational and 3 interventional, mainly involving children with hematologic malignancies) were included. One study which analyzed 25OHD as a threshold variable (≤10 ng/ml) found a significant association between 25OHD levels and BMD Z-scores, while 25OHD as a continuous variable was not significantly associated with BMD Z-scores in 14 observational studies. We found neither a significant association between lower 25OHD levels and fractures (2 studies), nor between vitamin D (and calcium) supplementation and BMD or fracture fr...Continue Reading

References

Nov 1, 1996·Journal of Pediatric Hematology/oncology·R C HendersonS H Gold
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HaltonR D Barr
Aug 14, 1998·Journal of Pediatric Hematology/oncology·R C HendersonS H Gold
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P LipsM F Holick
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M BootS M de Muinck Keizer-Schrama
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·N BinkleyM K Drezner
Aug 9, 2005·Hematology·Magdy A El-ZinyAshraf A Elsharkawy
Apr 28, 2006·Pediatric Research·Elena RuzaAna Patiño-Garcia
Jun 28, 2007·JAMA : the Journal of the American Medical Association·Maud M GeenenFlora E van Leeuwen
Aug 21, 2007·Bone·Maria Luisa Bianchi
Dec 20, 2007·Pediatric Hematology and Oncology·Magdy A El-ZinyAshraf A Elsharkawy
Jan 8, 2008·Journal of Pediatric Hematology/oncology·Paulina R DíazDunny M Casanova
May 6, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Aug 5, 2008·Pediatrics·Madhusmita MisraUNKNOWN Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Mar 11, 2010·Journal of Pediatric Hematology/oncology·Adalet Meral GunesBirol Baytan
Jul 2, 2010·Journal of Oncology Practice·Qamar J Khan, Carol J Fabian
Apr 9, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ghada El-Hajj FuleihanM Abboud
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Paul Lips, Natasja M van Schoor
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jun 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S FerrariUNKNOWN IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology
Aug 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Sogol Mostoufi-MoabMary B Leonard
Nov 7, 2012·Hormone Research in Pædiatrics·Roxana Aguirre CastanedaSeema Kumar
Feb 20, 2013·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
Nov 7, 2013·Pediatric Blood & Cancer·Adam J EsbenshadeDebra L Friedman
Jul 6, 2014·Current Osteoporosis Reports·Sogol Mostoufi-Moab, Jacqueline Halton
Jul 31, 2014·Age and Ageing·Opinder Sahota
Sep 12, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M A H den HoedM M van den Heuvel-Eibrink
May 15, 2015·Pediatric Blood & Cancer·Jung Woo HanChuhl Joo Lyu
Oct 30, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M WeaverD D Wang
Jan 9, 2016·The Journal of Clinical Endocrinology and Metabolism·Craig F MunnsWolfgang Högler
Apr 24, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Hyoung Soo ChoiHye Ran Yang
Aug 20, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Worawut ChoeyprasertPimlak Charoenkwan
Oct 28, 2016·Archives of Osteoporosis·Mohammad Reza BordbarForough Saki

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