Abstract
Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. Seventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D < 30 ng/mL) were recruited. Patients received oral cholecalciferol 50,000 units once a week for 12 weeks. Changes in endothelial function by brachial artery flow-mediated dilation (FMD), soluble vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were studied. There was a significant increase in serum levels of 25(OH)D after cholecalciferol supplementation (33.7 ± 12.1 vs. 13.2 ± 5.4 ng/mL, P < 0.001). Multivariable regression analysis showed that higher proteinuria (β = - 0.548, P < 0.001) and lower levels of 25(OH)D (β = 0.360, P < 0.001) at baseline were related to lower 25(OH)D level after supplementation. FMD increased significantly from 4.4 ± 1.3 to 5.1 ± 1.5% (P < 0.001), and soluble endothelial biomarkers decreased: sVCAM-1 from 926.9 ± 158.0 to 867.0 ± 129.0 ng/mL (P < 0.001), and sE-selectin 69.7 ± 15.8 to 63.3 ± 14.7 ng/mL (P < 0.001). Vitamin D supplementation can improve endot...Continue Reading
References
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Sep 18, 2002·Kidney International·Ronald M A HenryCoen D A Stehouwer
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 14, 2005·Kidney International·Adeera Levin, Yan Chun Li
Jul 11, 2006·Journal of the American Society of Nephrology : JASN·Kerstin AmannEberhard Ritz
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Gérard M LondonFabien Mëtivier
Feb 19, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·J A SugdenA D Struthers
Jun 3, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Ozlem TarcinSema Akalin
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M D WithamA D Struthers
Feb 12, 2011·American Journal of Hypertension·Ryan A HarrisYanbin Dong
Jul 2, 2011·Journal of the American College of Cardiology·Ibhar Al MheidArshed A Quyyumi
Nov 11, 2011·Atherosclerosis·Nihil ChitaliaDebasish Banerjee
Dec 22, 2011·American Journal of Therapeutics·Anton LishmanovAnand Chockalingam
Nov 13, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Sun Moon KimChun Soo Lim
Mar 22, 2014·PloS One·Nihil ChitaliaDebasish Banerjee
Dec 18, 2014·Journal of Nephrology·Qing-Yan ZhangMiao Zhang
Sep 10, 2015·The American Journal of the Medical Sciences·Diane L Kamen, Jim C Oates
Jul 1, 2016·Hemodialysis International·Yusuf KarakasBasar Sirmagul
Citations
Jun 16, 2019·Medicina·Guido GembilloDomenico Santoro
Jul 18, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S Tony Wolf, W Larry Kenney
Oct 31, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gurpreet KaurJuhi Kumar
Aug 11, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Chun Hu, Xiaoyan Wu
Jul 11, 2019·Archives of Physiology and Biochemistry·Raghad Khalid Al-IshaqDietrich Büsselberg
Nov 21, 2018·International Urology and Nephrology·Ashok Kumar YadavDebasish Banerjee
Feb 27, 2020·Nutrients·Do-Houn KimRobert C Hickner
Dec 7, 2018·Nutrition & Metabolism·Reza TabriziZatollah Asemi
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·S Tony WolfW Larry Kenney
Mar 20, 2021·Expert Review of Anti-infective Therapy·Anindita BanerjeeSasanka Chakrabarti
Apr 2, 2021·International Journal of Nephrology·Naowanit NataBancha Satirapoj
Aug 28, 2021·Life·Elisa GrazioliAnnalisa Noce