Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Journal of Diabetes Research
Sue PenckoferDiane E Wallis

Abstract

The aim of this study was to determine the effect of vitamin D supplementation on improving mood (depression and anxiety) and health status (mental and physical) in women with type 2 diabetes mellitus (T2DM). Fifty women with T2DM and significant depressive symptomology were enrolled into the "Sunshine Study," where weekly vitamin D supplementation (ergocalciferol, 50,000 IU) was given to all participants for six months. The main outcomes included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) health status (Short Form, SF-12). Forty-six women (92%) completed all visits. There was a significant decrease in depression (CES-D and PHQ-9, p < 0.001) and anxiety (state and trait, p < 0.001). An improvement in mental health status (SF-12, p < 0.001) was also found. After controlling for covariates (race, season of enrollment, baseline vitamin D, baseline depression (PHQ-9), and body mass index), the decline in depression remained significant (CES-D, p < 0.001). There was a trend for a better response to supplementation for women who were not taking medications for mood (antidepressants or anxiolytics) (p = 0.07). Randomized trial...Continue Reading

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Citations

May 31, 2019·Neurological Research·Giulia BivonaMarcello Ciaccio
May 17, 2019·CNS Drugs·Gleicilaine A S CassebAna Lúcia S Rodrigues
Jun 17, 2020·Frontiers in Neurology·Michelle E Fullard, John E Duda
Dec 15, 2019·Journal of Molecular Neuroscience : MN·Shareefa AlghamdiFrank I Tarazi
Feb 13, 2021·International Journal of Environmental Research and Public Health·Hanan AlfawazNasser M Al-Daghri

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Methods Mentioned

BETA
blood draw
cognitive behavioral therapy

Software Mentioned

VITAL

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