Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice

Immunologic Research
Anand DusadJill A Poole

Abstract

Systemic bone loss is associated with airway inflammatory diseases; yet, strategies to halt disease progression from inhalant exposures are not clear. Vitamin D might be a potentially protective approach against noxious respirable environmental exposures. We sought to determine whether vitamin D supplementation represents a viable lung- and bone-protective strategy following repetitive inhalant treatments with organic dust extract (ODE) or lipopolysaccharide (LPS) in mice. C57BL/5 mice were maintained on diets with low (1 IU/D/g) or high (10 IU/D/g) vitamin D for 5 weeks and treated with ODE from swine confinement facilities, LPS, or saline daily for 3 weeks per established intranasal inhalation protocol. Lungs, hind limbs, and sera were harvested for experimental outcomes. Serum 25-hydroxyvitamin D levels were tenfold different between low and high vitamin D treatment groups with no differences between inhalant agents and saline treatments. Serum calcium levels were not affected. There was no difference in the magnitude of ODE- or LPS-induced inflammatory cell influx or lung histopathology between high and low vitamin D treatment groups. However, high vitamin D treatment reversed the loss of bone mineral density, bone volume, ...Continue Reading

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Citations

Oct 6, 2015·Journal of Toxicology and Environmental Health. Part a·Jill A PooleKristina L Bailey
Nov 23, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Adam WellsJill A Poole
Feb 23, 2018·Current Allergy and Asthma Reports·Joseph M Carrington, Jill A Poole
Mar 27, 2021·Current Allergy and Asthma Reports·Mia IsaakCorrine Hanson

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