Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial

BMC Research Notes
Peter BergmanLinda Björkhem-Bergman

Abstract

Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs. We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here). Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95% CI 0.43-0.94). Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05). Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95% CI 1.03-2.68, p = 0.0376). Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This coul...Continue Reading

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References

Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tian-Tian WangJohn H Hanrahan
Jan 5, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katherine B GibneyBeverley-Ann Biggs
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adrian R MartineauRobert J Wilkinson

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Citations

Apr 17, 2016·BMJ Supportive & Palliative Care·Linda Björkhem-Bergman, Peter Bergman
Sep 15, 2017·BMJ Supportive & Palliative Care·Maria Helde-FranklingLinda Björkhem-Bergman
May 30, 2020·Aging·Amber L MuellerDavid A Sinclair
Sep 12, 2020·Irish Journal of Psychological Medicine·D Viani-WalshJ Lally

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NCT01131858

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