Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial

JAMA : the Journal of the American Medical Association
Ravi ThadhaniScott D Solomon

Abstract

Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking. To determine the effects of an active vitamin D compound, paricalcitol, on left ventricular mass over 48 weeks in patients with an estimated glomerular filtration rate of 15 to 60 mL/min/1.73 m(2). Multinational, double-blind, randomized placebo-controlled trial among 227 patients with chronic kidney disease, mild to moderate left ventricular hypertrophy, and preserved left ventricular ejection fraction, conducted in 11 countries from July 2008 through September 2010. Participants were randomly assigned to receive oral paricalcitol, 2 μg/d (n =115), or matching placebo (n = 112). Change in left ventricular mass index over 48 weeks by cardiovascular magnetic resonance imaging. Secondary end points included echocardiographic changes in left ventricular diastolic function. Treatment with paricalcitol reduced parathyroid hormone levels within 4 weeks and maintained levels within the normal range throughout the study duration. At 48 weeks, the change in left ventricular mass index did not differ between treatment groups (paricalcitol group, 0.34 g/m...Continue Reading

Citations

Oct 15, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Piergiorgio MessaCarlo Maria Alfieri
Dec 3, 2013·International Journal of Clinical Pharmacy·Michelle A King, Rebecca L Pryce
Nov 1, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Janine PössMichael Böhm
Dec 3, 2013·The International Journal of Cardiovascular Imaging·Ron WaldAndrew T Yan
Nov 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ernesto Paoletti, Carmine Zoccali
Oct 6, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Stuart M Sprague, Sharon M Moe
Nov 1, 2013·Archives of Toxicology·Stefan PilzWinfried März
Oct 31, 2012·European Heart Journal·Gunnar H HeineDanilo Fliser
Dec 15, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Uwe Querfeld
Jun 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tamara IsakovaPaolo G Rusconi
Mar 8, 2013·American Journal of Nephrology·Flore DurantonAngel Argilés
Dec 19, 2012·Nature Reviews. Nephrology·Parta HatamizadehKamyar Kalantar-Zadeh
Jan 9, 2013·Nature Reviews. Nephrology·Pranav S Garimella, Mark J Sarnak
Apr 24, 2013·Nature Reviews. Nephrology·Sujana S GuntaRobert H Mak
Mar 8, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A Beveridge, M D Witham
Dec 4, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M CozzolinoM Gallieni
Jun 6, 2013·Blood Purification·Antonio BellasiMario Cozzolino
Aug 7, 2013·Orphanet Journal of Rare Diseases·Frank WeidemannAlberto Ortiz
Apr 24, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard S Fish, John Cunningham
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine Zoccali
Jan 4, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emilio Gonzalez-ParraJesus Egido
Sep 10, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sara PanizoJorge B Cannata-Andía
Jan 10, 2013·Current Opinion in Nephrology and Hypertension·Hector TamezRavi I Thadhani
May 15, 2013·Current Opinion in Nephrology and Hypertension·Ishir BhanRavi Thadhani
Oct 9, 2013·Current Opinion in Nephrology and Hypertension·Sharon M Moe, Ravi Thadhani
Mar 26, 2013·Expert Opinion on Pharmacotherapy·Masafumi FukagawaTakatoshi Kakuta
Apr 30, 2013·Expert Opinion on Drug Safety·Christopher A Dyer
Feb 24, 2015·Expert Opinion on Emerging Drugs·Mario CozzolinoAntonio Bellasi
Jul 28, 2015·Renal Failure·Nan ZhuWeijie Yuan
Jan 4, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Eva GravesenKlaus Olgaard
Sep 1, 2012·Scandinavian Cardiovascular Journal : SCJ·Armin ZittermannJochen Börgermann
Dec 27, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Jesús EgidoCarlos Solozábal
Jan 20, 2016·Current Opinion in Nephrology and Hypertension·Andrew L Lundquist, Sagar U Nigwekar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.