Vitamin D to Prevent Lung Injury Following Esophagectomy-A Randomized, Placebo-Controlled Trial

Critical Care Medicine
Dhruv ParekhDavid R Thickett

Abstract

Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness and identify it as a potential risk factor for the development of lung injury. To determine whether preoperative administration of oral high-dose cholecalciferol ameliorates early acute lung injury postoperatively in adults undergoing elective esophagectomy. A double-blind, randomized, placebo-controlled trial. Three large U.K. university hospitals. Seventy-nine adult patients undergoing elective esophagectomy were randomized. A single oral preoperative (3-14 d) dose of 7.5 mg (300,000 IU; 15 mL) cholecalciferol or matched placebo. Primary outcome was change in extravascular lung water index at the end of esophagectomy. Secondary outcomes included PaO2:FIO2 ratio, development of lung injury, ventilator and organ-failure free days, 28 and 90 day survival, safety of cholecalciferol supplementation, plasma vitamin D status (25(OH)D, 1,25(OH)2D, and vitamin D-binding protein), pulmonary vascular permeability index, and extravascular lung water index day 1 postoperatively. An exploratory study measured biomarkers of alveolar-capillary inflammation and injury. Forty patients were randomized to cholecalciferol and 39 to p...Continue Reading

References

Sep 29, 2001·British Journal of Anaesthesia·S TandonS V Baudouin
Oct 31, 2001·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·N SatoS Endo
Jun 25, 2003·British Journal of Anaesthesia·S V Baudouin
Mar 23, 2004·Annals of the New York Academy of Sciences·Alessandra Pagano, Constance Barazzone-Argiroffo
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Gavin D PerkinsFang Gao
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Jan 24, 2008·Nature Clinical Practice. Endocrinology & Metabolism·John S Adams, Martin Hewison
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sif HansdottirGary W Hunninghake
May 1, 2009·The New England Journal of Medicine·Paul LeeJacqueline R Center
Aug 8, 2009·American Journal of Respiratory and Critical Care Medicine·Stéphanie CarnesecchiConstance Barazzone Argiroffo
Dec 17, 2009·Critical Care : the Official Journal of the Critical Care Forum·Daniel P ParkGavin D Perkins
Aug 31, 2010·American Journal of Respiratory and Critical Care Medicine·Ognjen GajicMichael Malinchoc
Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Thelma R CraigDaniel F McAuley
Nov 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Anand KrishnanBala Venkatesh
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Natasja M van Schoor, Paul Lips
Sep 20, 2011·Critical Care Medicine·Andrea B BraunKenneth B Christopher
Oct 7, 2011·Endocrine Research·Ulrich C BangJens-Erik Beck Jensen
Sep 15, 2012·Critical Care Medicine·Andrea B BraunKenneth B Christopher
Oct 19, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Sadeq A Quraishi, Carlos A Camargo
Jun 21, 2013·Inflammation & Allergy Drug Targets·Dhruv ParekhAlice M Turner
Aug 16, 2013·The American Journal of Clinical Nutrition·Sadeq A QuraishiKenneth B Christopher
Aug 29, 2013·Critical Care Medicine·Takuhiro MoromizatoKenneth B Christopher
Jan 8, 2014·American Journal of Respiratory and Critical Care Medicine·Gavin D PerkinsUNKNOWN BALTI-Prevention Collaborators
May 29, 2014·International Journal of Endocrinology·Pegah YousefzadehXiangbing Wang
Oct 8, 2014·Chest·Jeremy R BeitlerB Taylor Thompson
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Renata Salatti Ferrari, Cristiano Feijó Andrade
Nov 8, 2015·Annals of Intensive Care·Mathieu JozwiakXavier Monnet
Feb 15, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Carl JenkinsonBrian G Keevil
May 18, 2016·JAMA : the Journal of the American Medical Association·Daryl J KorUNKNOWN US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A)
Sep 16, 2016·Critical Care Medicine·Dhruv ParekhDavid R Thickett

❮ Previous
Next ❯

Citations

Nov 18, 2018·Critical Care Medicine·Salman Ahmad
May 27, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Hatice Aygun
Nov 30, 2019·Expert Opinion on Investigational Drugs·Pedro Leme SilvaPatricia R M Rocco
Jun 6, 2019·Critical Care : the Official Journal of the Critical Care Forum·Gennaro MartucciKarin Amrein
Dec 6, 2020·Current Opinion in Critical Care·Hector GonzalezJohn G Laffey
Jan 4, 2021·The Journal of Nutritional Biochemistry·Shaniya AhmadMansoor Ali Syed
Jan 26, 2021·Clinical Nutrition ESPEN·Melika Hajimohammadebrahim-KetabforoushZahra Vahdat Shariatpanahi
Sep 4, 2020·Seminars in Respiratory and Critical Care Medicine·Gennaro MartucciKarin Amrein

❮ Previous
Next ❯

Clinical Trials Mentioned

ISRCTN27673620

Software Mentioned

Graphpad PRISM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.