Vitamin D3-Loaded Nanostructured Lipid Carriers as a Potential Approach for Fortifying Food Beverages; in Vitro and in Vivo Evaluation

Advanced Pharmaceutical Bulletin
Maryam MohammadiHamed Hamishehkar

Abstract

Purpose: Nanostructured lipid carriers (NLCs) composed of solid lipid and oil are a new generation of lipid nanoparticles which have exhibited some merits over traditional used lipid nanoparticles in fortifying food and beverages and nutraceuticals delivery systems such as liposomes and solid lipid nanoparticles. Methods: In this study, Precirol and Compritol as solid lipids, Miglyol and Octyloctanoat as liquid lipids, Tween80, Tween20 and Poloxamer407 as surfactants were used to prepare vitamin D3-loaded NLC dispersion using hot homogenization method. The particle size and size distribution for all formulations were evaluated by immediately after production and during a storage period of 60 days. Results: The Precirol-based NLC showed superiority over Compritol-based NLC in the point of physical stability. Results clearly suggested that an optimum concentration of 3% of Poloxamer407 or 2% of Tween20 was sufficient to cover the surface of nanoparticles effectively and prevent agglomeration during the homogenization process. Octyloctanoat was introduced for the first time as a good substituent for Miglyol in the preparation of NLC formulations. The vitamin D3 Intestinal absorption enhanced by the incorporating in NLCs. Conclusio...Continue Reading

References

Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
May 16, 2002·Biomaterials·Rita CortesiClaudio Nastruzzi
Aug 15, 2002·International Journal of Pharmaceutics·R H MüllerS A Wissing
Apr 25, 2003·International Journal of Pharmaceutics·Michele TrottaOtto Caputo
Mar 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·G ZuccariI Orienti
Jul 19, 2005·International Journal of Pharmaceutics·Rajesh PandeyG K Khuller
Jul 3, 2007·Advanced Drug Delivery Reviews·R H MüllerJ Pardeike
Oct 20, 2007·International Journal of Pharmaceutics·Ajit S NarangDanchen Gao
Aug 12, 2008·Journal of the American College of Nutrition·Miriam BlumBess Dawson-Hughes
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
Dec 17, 2008·Recent Patents on Drug Delivery & Formulation·Krutika K Sawant, Shamsunder S Dodiya
Apr 22, 2009·Journal of Colloid and Interface Science·T HelgasonJ Weiss
Sep 4, 2009·Micron : the International Research and Review Journal for Microscopy·Nispa SeetapanUracha Rungsardthong Ruktanonchai
Jan 12, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chih-Chieh ChenJia-You Fang
May 21, 2010·Arquivos brasileiros de endocrinologia e metabologia·Iara Maria Gomes CoelhoFrancisco Bandeira
Oct 27, 2010·AAPS PharmSciTech·Ketan HippalgaonkarViral Kansara
Mar 9, 2011·Acta Dermato-venereologica·William G Tsiaras, Martin A Weinstock
Jun 10, 2011·Colloids and Surfaces. B, Biointerfaces·Loo Chew HungChoo Yuen May
Jul 19, 2011·Colloids and Surfaces. B, Biointerfaces·M KakranL Li
Apr 6, 2012·Advances in Colloid and Interface Science·David Julian McClements
Jun 6, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Surajit DasReginald B H Tan
Jan 22, 2014·Colloids and Surfaces. B, Biointerfaces·Nisharani S RanpiseVinod N Ghodake
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Elisabetta EspositoRita Cortesi

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Citations

Oct 12, 2019·Parasites & Vectors·Ehsan AhmadpourGregorio Perez-Cordon
Jul 22, 2019·Pharmaceutics·Eliza GlowkaJanina Lulek
Feb 3, 2020·International Journal of Biological Macromolecules·Maryam MohammadiHamed Hamishehkar
Nov 17, 2019·Food Research International·Mahesh Kharat, David Julian McClements
Jun 19, 2021·International Journal of Nanomedicine·Taiki MiyazawaTeruo Miyazawa

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Methods Mentioned

BETA
light scattering
enzyme-linked immunosorbent assays

Software Mentioned

SPSS

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