Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats

The Journal of Nutritional Biochemistry
Peeyush T KumarChiramadathikudiyil Skaria Paulose

Abstract

Nutritional therapy is a challenging but necessary dimension in the management of diabetes and neurodegenerative changes associated with it. The study evaluates the effect of vitamin D(3) in preventing the altered function of cholinergic, insulin receptors and GLUT3 in the cerebral cortex of diabetic rats. Muscarinic M3 acetylcholine receptors in pancreas control insulin secretion. Vitamin D(3) treatment in M3 receptor regulation in the pancreatic islets was also studied. Radioreceptor binding assays and gene expression was done in the cerebral cortex of male Wistar rats. Immunocytochemistry of muscarinic M3 receptor was studied in the pancreatic islets using specific antibodies. Y-maze was used to evaluate the exploratory and spatial memory. Diabetes induced a decrease in muscarinic M1, insulin and vitamin D receptor expression and an increase in muscarinic M3, α7 nicotinic acetylcholine receptor, acetylcholine esterase and GLUT3 expression. Vitamin D(3) and insulin treatment reversed diabetes-induced alterations to near control. Diabetic rats showed a decreased Y-maze performance while vitamin D(3) supplementation improved the behavioural deficit. In conclusion, vitamin D(3) shows a potential therapeutic effect in normalizing...Continue Reading

References

Nov 1, 1992·Endocrine Reviews·M R Walters
May 1, 1990·Behavioral and Neural Biology·A C SantucciD C Riccio
Nov 1, 1969·The Journal of Clinical Investigation·A JunodA E Renold
Jun 1, 1968·The Biochemical Journal·S L Howell, K W Taylor
Jul 1, 1968·The Journal of General Physiology·C R ParkT Kono
Jan 1, 1969·British Journal of Pharmacology·A K ArmitageC M Sellers
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F MaherI A Simpson
Sep 14, 1999·The American Journal of Medicine·D A GreeneE L Feldman
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C McNayP E Gold
Oct 12, 2000·Neuroscience Letters·J Jackson-GuilfordL K Nisenbaum
Aug 30, 2002·Neurotoxicology and Teratology·A NittaS Furukawa
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ute ZeitzReinhold G Erben
May 10, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rosane de Souza Santos, Lucia Marques Vianna

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Citations

Mar 20, 2013·Molecular Aspects of Medicine·Sara El-GebaliPascale Anderle
Jun 10, 2015·The Journal of Nutritional Biochemistry·Sadanandan JayanarayananCheramadathikudiyil Skaria Paulose
Jun 21, 2014·Cell Biochemistry and Function·Nicéia Spanholi CalgarotoMaria Rosa Chitolina Schetinger
Oct 23, 2015·Advances in Pharmacological Sciences·Mohamed Naguib ZakariaWaleed Barakat
Jun 11, 2016·Neuromolecular Medicine·Duygu Gezen-AkErdinç Dursun
Dec 29, 2011·American Journal of Alzheimer's Disease and Other Dementias·Khanh Vinh Quôc Lu'o'ng, Lan Thi Hoàng Nguyên
Mar 30, 2019·The British Journal of Nutrition·Zoé M GuareschiSabrina Grassiolli
May 7, 2019·Frontiers in Molecular Neuroscience·Andrea N SuarezScott E Kanoski
Feb 18, 2016·Implant Dentistry·Fawad JavedGeorgios E Romanos

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