Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C

FEBS Letters
Amparo GimenoVicente J Miralles

Abstract

The treatment of human fibroblasts with different tocopherols in the presence of retinol caused an increase in cytoplasmic retinoic acid binding protein II (CRABP-II) mRNA and protein. The possibility of an involvement of protein kinase C (PKC) in the response to tocopherols was supported by the results obtained with the PKC-specific inhibitors, calphostin C and bisindolylmaleimide I. The effect of alpha-tocopherol was prevented by okadaic acid, suggesting that a protein phosphatase is responsible for PKC dephosphorylation produced by the presence of tocopherols. The results shown support the hypothesis that phosphorylation/dephosphorylation of RXRalpha via PKC may be involved in the regulation of CRABP-II gene expression.

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J C HsiehM R Haussler
Jan 1, 1989·Annual Review of Biochemistry·P Cohen
Mar 1, 1996·The Journal of Investigative Dermatology·J T ElderJ J Voorhees
Jan 1, 1996·Annual Review of Nutrition·E Li, A W Norris
Jun 22, 1999·The Journal of Clinical Investigation·D Shao, M A Lazar
Aug 12, 2000·The Journal of Biological Chemistry·H Y LeeJ M Kurie
May 10, 2002·The Journal of Biological Chemistry·Goran BoskovicRichard M Niles
Sep 27, 2002·The American Journal of Clinical Nutrition·Regina Brigelius-FlohéAngelo Azzi
Dec 31, 2002·Biochemical Pharmacology·Nico LandesRegina Brigelius-Flohé

❮ Previous
Next ❯

Citations

Mar 15, 2011·Toxicon : Official Journal of the International Society on Toxinology·Vanessa ValdiglesiasJosefina Méndez
Jan 10, 2009·Free Radical Biology & Medicine·Regina Brigelius-Flohé
Aug 16, 2014·International Wound Journal·Rachel Hobson
Sep 20, 2005·Neurobiology of Learning and Memory·Siomara C MonteiroAngela T S Wyse
Aug 20, 2011·The Biochemical Journal·F Xavier RuizXavier Parés
Jul 11, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Isaac TúnezPedro Montilla
Aug 24, 2018·Nutrients·Joaquín TimonedaTeresa Barber
Dec 1, 2006·Nutrition Research Reviews·Regina Brigelius-Flohé
Jun 10, 2021·Current Developments in Nutrition·Matthew J KuchanXinhua Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.