Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys

The American Journal of Physiology
J F ReckelhoffA K Salahudeen

Abstract

Aging results in progressive glomerular sclerosis and reductions in glomerular filtration rate (GFR). Oxidative stress may be an important mechanism for the aging process, but to date the role of oxidative stress on renal aging has not been determined. The present study was performed to determine whether age-related alterations in renal hemodynamics and morphology were associated with oxidative stress and whether this could be attenuated by chronic administration of vitamin E. Rats, aged 13 mo, were given either control diet containing vitamin E 50 IU/kg (n = 6) or a high-vitamin E diet (5,000 IU/kg; n = 6) for 9 mo. Another group of rats (3-4 mo old; n = 7) served as young controls. Aging was accompanied by a 60% reduction in GFR, a threefold increase in renal F2 isoprostanes, newly discovered vasoconstrictive F2-like prostaglandins generated by free radical-mediated lipid peroxidation. Renal aging was also associated with an increase in oxidant-sensitive heme oxygenase, advanced glycosylation end products (AGEs), and the AGE receptor, RAGE. AGE-RAGE interaction has been shown to induce oxidative stress. With high-vitamin E diet, GFR was increased by 50%, F2 isoprostanes were suppressed, and expression of heme oxygenase and RA...Continue Reading

References

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Citations

Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana NavarroAlberto Boveris
Sep 19, 2008·American Journal of Physiology. Renal Physiology·Ho-Shiang HuangJun Chen
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johannes LeiererGert Mayer
Apr 22, 2017·Free Radical Research·Khalil Ali AhmadDing Qilong
Oct 8, 2005·American Journal of Physiology. Renal Physiology·Jane F ReckelhoffJoey P Granger
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·N TianR D Manning
Jan 4, 2007·American Journal of Physiology. Renal Physiology·You-Lin TainChris Baylis
Jun 21, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason A PayneRaouf A Khalil
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lourdes A Fortepiani, Jane F Reckelhoff
May 18, 2018·Oxidative Medicine and Cellular Longevity·Grazia TammaGiuseppe Calamita

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