Vitamin E analog alpha-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice

Breast Cancer Research and Treatment
Shuo ZhangKimberly Kline

Abstract

Alpha-TEA, a nonhydrolyzable ether analog of vitamin E (RRR-alpha-tocopherol), and celecoxib, a specific COX-2 inhibitor, were delivered separately or in combination to investigate their anticancer properties, using MDA-MB-435-FL-GFP human breast cancer xenografts in nude mice. Liposomal formulated alpha-TEA administered as an aerosol and celecoxib fed at 500 or 1250 mg/kg diet for 31 days separately or in combination significantly reduced tumor volume in comparison to control (p < 0.001 for all treatment groups). Of special note, the combinations of alpha-TEA + celecoxib (1250) inhibited tumor volume significantly better than either single treatment (p < 0.001 and p < 0.001). Average number of macroscopic lung metastases were significantly reduced in all treatment groups in comparison to control, with the exception of celecoxib (500). Mean numbers of microscopic lung and lymph node metastases in all treatment groups were significantly lower than control. Furthermore, the mean number of microscopic lung metastases in the alpha-TEA+celecoxib (1250) group were significantly lower than either separate treatment. Analyses of 5 microm tumor sections showed that all treatments, with the exception of celecoxib (500) alone, significant...Continue Reading

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Citations

Jul 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Weiping YuKimberly Kline
Oct 12, 2007·Nutrition and Cancer·Nanjoo SuhHarold L Newmark
May 15, 2007·Molecular Aspects of Medicine·Jiri NeuzilStephen J Ralph
Oct 6, 2015·Biochimica Et Biophysica Acta·Ileana Hernández-ReséndizSara Rodríguez-Enríquez
May 12, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Sriram AmbadapadiMargaret O James
May 31, 2008·International Journal of Cancer. Journal International Du Cancer·Constantina ConstantinouAndreas I Constantinou
Dec 17, 2008·Molecular Nutrition & Food Research·Yan ZhaoKun Wu
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Jul 14, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Li-Quan Wang, Margaret O James
Apr 12, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stepan KoudelkaJaroslav Turanek
Dec 25, 2013·Nutrition and Cancer·Aracely Angulo-MolinaJesús Hernández
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