PMID: 12897039Aug 5, 2003Paper

Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review

Journal of the American College of Nutrition
Anand Dutta, Sudhir K Dutta

Abstract

Epidemiological and experimental studies suggest that antioxidants like vitamin E (alpha-tocopherol) may play an important role in prevention of chronic disease. Several observational surveys have linked populations with a large intake of vitamin E with reduced incidence of heart disease. These observations have been strengthened by the demonstration of strong antioxidant activity by vitamin E in cellular, molecular and animal experiments. These results have highlighted a potential role for vitamin E supplementation in the prevention of chronic disease in humans. Interestingly however, large-scale clinical trials of vitamin E and other antioxidants in preventing specific disease processes (e.g., coronary artery disease) have generated conflicting and mixed outcomes. In this review, the role of vitamin E in the prevention of atherosclerosis and carcinogenesis has been carefully examined with particular emphasis on salient human studies (clinical trials) and their limitations. In addition, pertinent biochemical, physiological and metabolic features of vitamin E have also been incorporated. A list of common natural food sources of vitamin E has been provided. Important in vitro and animal studies related to the antiatherosclerotic...Continue Reading

References

Nov 1, 1992·Metabolism: Clinical and Experimental·M ToborekE Kopieczna-Grzebieniak
Jan 1, 1991·The American Journal of Clinical Nutrition·G T VatasseryM A Kuskowski
Dec 1, 1986·The American Journal of Clinical Nutrition·M G TraberM H Green
Apr 1, 1982·The American Journal of Clinical Nutrition·W A BehrensR Madère
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D HarnettP S Parfrey
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
Jan 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P S Parfrey
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
May 20, 1993·The New England Journal of Medicine·E B RimmW C Willett
May 2, 1997·The Journal of Biological Chemistry·T ItoW S May
Aug 7, 1997·The New England Journal of Medicine·M N DiazJ F Keaney
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R A WoutersenA Van Garderen-Hoetmer
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Jan 4, 2001·Drug Metabolism Reviews·E S KrolD C Liebler
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J NeuzilC Weber
Feb 7, 2001·The American Journal of Clinical Nutrition·M E KeithM J Sole
Feb 13, 2001·The Journal of Nutrition·M Meydani
Feb 13, 2001·The Journal of Nutrition·I JialalN Kaul
Feb 24, 2001·The Journal of Nutrition·K KlineB G Sanders
Mar 7, 2001·Antioxidants & Redox Signaling·A Stocker, A Azzi
Apr 17, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S R ThomasR Stocker
Jun 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·R B WeinbergM J Thomas
Oct 1, 1993·European Journal of Cancer. Part B, Oral Oncology·J SchwartzD Trickler
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Feb 28, 2002·Circulation Research·Andrew C TerentisRoland Stocker

❮ Previous
Next ❯

Citations

Jan 31, 2009·Aging Clinical and Experimental Research·Sheau C ChaiBahram H Arjmandi
May 20, 2009·American Journal of Therapeutics·Adonis Saremi, Rohit Arora
Dec 8, 2010·Respiratory Research·Ioanna G Tsiligianni, Thys van der Molen
Jan 1, 2010·Journal of Nutritional Science and Vitaminology·Mansour KarajibaniMadhurima Dikshit
Nov 5, 2013·Nutrients·Hiam Abdala-ValenciaJoan M Cook-Mills
Oct 4, 2013·Journal of Osteoporosis·Rafaela G FeresinBahram H Arjmandi
Aug 3, 2013·American Journal of Respiratory and Critical Care Medicine·Joan M Cook-MillsTina Hartert
Nov 16, 2014·Cardiovascular Drugs and Therapy·Andrea J CurtisJohn J McNeil
May 7, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Deniz KiracNesrin Kartal Ozer
Dec 2, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Niki Katsiki, Christos Manes
Dec 28, 2007·Free Radical Biology & Medicine·Jeffrey AtkinsonRichard M Epand
Jul 27, 2007·The Journal of Nutritional Biochemistry·Simone G J van BredaJoost H M van Delft
Jul 13, 2007·Molecular Aspects of Medicine·Jean-Marc Zingg
Jul 1, 2009·International Journal of Experimental Pathology·Siti Khadijah AdamKamsiah Jaarin
Nov 28, 2008·International Journal of Cancer. Journal International Du Cancer·Anne C M ThiébautFrançoise Clavel-Chapelon
Aug 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J M Tucker, D M Townsend
Jun 9, 2004·Clinics in Geriatric Medicine·Julie K Gammack, John E Morley
Jan 24, 2009·Redox Report : Communications in Free Radical Research·A Magon de la VillehuchetA Kontush
Jan 16, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Tan Kai XianFarida Hussan
Apr 6, 2005·Reproductive Toxicology·Rada BoskovicGideon Koren
Feb 26, 2005·Biology of the Neonate·Ulla HoppuErika Isolauri
Mar 17, 2016·World Journal of Biological Chemistry·Lisa SchmölzMaria Wallert
Jan 13, 2006·Carcinogenesis·Connie S Chen, Peter G Wells
Jun 17, 2006·Skin Pharmacology and Physiology·M DarvinJ Lademann
Jul 13, 2019·International Journal of Food Sciences and Nutrition·Yukyung ChoiYohan Yoon
Jan 5, 2008·The Journal of Pharmacology and Experimental Therapeutics·Anthony Y H WooChristopher H K Cheng
Sep 8, 2007·The American Journal of Clinical Nutrition·David L RainwaterXing Li Wang
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergejs BerdnikovsJoan M Cook-Mills
Apr 9, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jan DobrovolnyJulie Bienertova-Vasku
Mar 23, 2019·Analytical and Bioanalytical Chemistry·Lucia BartellaFabio Mazzotti
Oct 13, 2020·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Kailash Prasad, Kalpana K Bhanumathy
May 19, 2006·Cancer Research·Véronique ChajèsVirginie Joulin
Nov 6, 2008·Journal of Agricultural and Food Chemistry·Jian-Guo Fang, Bo Zhou
Apr 15, 2010·Journal of Agricultural and Food Chemistry·Jennifer TroxHans Konrad Biesalski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.