Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Matthew J Picklo, John P Thyfault

Abstract

Controversy exists as to whether supplementation with the antioxidants vitamin E and vitamin C blocks adaptation to exercise. Exercise is a first-line means to treat obesity and its complications. While diet-induced obesity alters mitochondrial function and induces insulin resistance (IR), no data exist as to whether supplementation with vitamin E and vitamin C modify responses to exercise in pre-existing obesity. We tested the hypothesis that dietary supplementation with vitamin E (0.4 g α-tocopherol acetate/kg) and vitamin C (0.5 g/kg) blocks exercise-induced improvements on IR and mitochondrial content in obese rats maintained on a high-fat (45% fat energy (en)) diet. Diet-induced obese, sedentary rats had a 2-fold higher homeostasis model assessment of insulin resistance and larger insulin area under the curve following glucose tolerances test than rats fed a low-fat (10% fat en) diet. Exercising (12 weeks at 5 times per week in a motorized wheel) of obese rats normalized IR indices, an effect not modified by vitamin E and vitamin C. Vitamin E and vitamin C supplementation with exercise elevated mtDNA content in adipose and skeletal muscle to a greater extent (20%) than exercise alone in a depot-specific manner. On the othe...Continue Reading

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Citations

Mar 30, 2016·Free Radical Biology & Medicine·Jose ViñaMari Carmen Gomez-Cabrera
Nov 14, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Juciano GasparottoDaniel Pens Gelain
Dec 8, 2015·The Journal of Physiology·Troy L Merry, Michael Ristow
Apr 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laelie A SnookDavid C Wright
Aug 6, 2017·The Journal of Endocrinology·Sergio Di MeoPaola Venditti
May 23, 2017·Frontiers in Endocrinology·Lewan ParkerItamar Levinger
Jun 6, 2018·Frontiers in Oncology·Sneha SundaramMatthew J Picklo
Nov 19, 2020·International Journal of Environmental Research and Public Health·Madalyn Riley HigginsMojtaba Kaviani

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