Abstract
Poly(etherurethane) elastomers are useful materials in medical devices because of their mechanical properties and biocompatibility. However, it is necessary to stabilize these elastomers against the oxidation of their ether soft segments. Synthetic antioxidants such as Santowhite and Irganox are often satisfactory; however, particularly for biomedical applications, it was of interest to test the natural antioxidant vitamin E in poly(etherurethane urea) (PEUU) elastomers in vivo. The alpha-tocopherol form of vitamin E was added to PEUU at 5% by weight. Biaxially strained PEUU specimens with and without vitamin E were tested in vivo in the cage implant system. The influence of vitamin E on PEUU biostability was analyzed by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and scanning electron microscopic (SEM) characterization of the PEUU surface. ATR-FTIR results showed that vitamin E prevented chemical degradation of the PEUU surface up to 5 weeks implantation, and at 10 weeks 82% of the ether remained. In contrast, without an antioxidant, only 18% of the ether remained after 10 weeks. No surface pitting or cracking was observed by SEM on PEUU with vitamin E; PEUU without antioxidant ruptured owin...Continue Reading
References
Aug 1, 1992·Journal of Biomedical Materials Research·O H ZhaoC R Payet
Jan 1, 1990·Cell Motility and the Cytoskeleton·J M HeipleS C Silverstein
Feb 1, 1966·The Journal of Cell Biology·J S Sutton, L Weiss
Jan 1, 1984·Biomaterials·J M Anderson, K M Miller
Mar 1, 1983·Journal of Biomedical Materials Research·R MarchantJ M Anderson
Jul 1, 1982·The Journal of Pathology·A R MurchJ M Papadimitriou
Mar 1, 1995·Journal of Biomedical Materials Research·M A SchubertJ M Anderson
Mar 1, 1993·Journal of Biomedical Materials Research·Q H ZhaoK Stokes
Jan 1, 1994·Methods in Enzymology·D C Liebler
Jan 21, 1995·Lancet·M Meydani
Mar 1, 1993·Journal of Biomedical Materials Research·G F MeijsK Schindhelm
Citations
Dec 18, 2001·Journal of Photochemistry and Photobiology. B, Biology·M BoultonB Rózanowski
Mar 21, 2007·Journal of Biomedical Materials Research. Part a·Stanley J StachelekRobert J Levy
Jul 20, 2007·Journal of Biomedical Materials Research. Part a·Chih-Wei ChouPey-Hwa Wang
Mar 23, 2010·Journal of Biomedical Materials Research. Part a·Stanley J StachelekRobert J Levy
Jul 26, 2005·Journal of Biomedical Materials Research. Part a·Mike EbertKen Stokes
Jan 21, 2006·Journal of Biomedical Materials Research. Part a·Bob WardKen Stokes
Mar 1, 2006·Journal of Biomedical Materials Research. Part a·Robert WardKen Stokes
Jan 13, 2015·Journal of Materials Science. Materials in Medicine·Marcos B SallesMarcelo Yoshimoto
Jun 25, 1998·Journal of Biomedical Materials Research·T CollierJ Anderson
Feb 6, 1999·Journal of Biomaterials Applications·R S LabowJ P Santerre
Jul 9, 1999·Journal of Biomedical Materials Research·L WuG Rosenberg
Aug 4, 2006·Journal of Biomedical Materials Research. Part a·Bob WardKen Stokes
Sep 8, 2006·Journal of Biomedical Materials Research. Part a·Robert WardKen Stokes
Feb 12, 2004·Journal of Biomaterials Science. Polymer Edition·M J ErnstingJ P Santerre
Jun 1, 2006·Journal of Biomedical Materials Research. Part a·Stanley J StachelekRobert J Levy
Jul 12, 2007·Journal of Biomaterials Science. Polymer Edition·Filippo RenòMario Cannas
Oct 8, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xingyi XieChangsheng Zhao
Jul 9, 1999·Journal of Biomedical Materials Research·C OrtizJ San Román
Mar 15, 1997·Journal of Biomedical Materials Research·M A SchubertA Hiltner
Jun 23, 2010·Journal of Biomaterials Science. Polymer Edition·Filippo RenòMario Cannas
Feb 27, 2004·Journal of Biomedical Materials Research. Part a·Michael J WigginsAnne Hiltner
Aug 4, 2006·Journal of Biomedical Materials Research. Part a·Robert WardKen Stokes
Aug 26, 2003·The American Journal of Pathology·Amy K McNally, James M Anderson