PMID: 2492442Jan 2, 1989Paper

Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence

Brain Research
J L CadetS Fahn

Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either D-alpha-tocopherol or all-racemic-alpha-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the free radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

References

Dec 17, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G W BurtonK U Ingold
Jun 1, 1986·Neurological Research·K MizoiT Yoshimoto
Jan 1, 1986·Annual Review of Physiology·W A Pryor
May 1, 1986·Medical Hypotheses·J L Cadet
Nov 1, 1985·Science·R Lewin
Jan 1, 1980·Annual Review of Neuroscience·G Jonsson
Oct 1, 1981·Brain Research·M Halks-MillerE A Smuckler
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich
Jan 1, 1980·Annals of the New York Academy of Sciences·A L Tappel
Jul 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A RechesS Fahn
Jan 8, 1981·Biochimica Et Biophysica Acta·M Steiner
Feb 1, 1973·FEBS Letters·A T. Diplock, J A. Lucy

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Citations

Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ranjita BetarbetJ Timothy Greenamyre
Jan 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·M B YoudimP Riederer
Aug 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·E I DanilovaV K Reshetniak
Oct 27, 2004·Cell and Tissue Research·Andreas Schober
Jun 1, 2006·Journal of Neural Transmission·M B H YoudimS Mandel
Aug 1, 1992·Journal of the Neurological Sciences·F J Jiménez-JiménezR Codoceo
Jan 1, 1994·Pharmacology & Therapeutics·M E GötzM B Youdim
Jul 9, 1993·Neuroscience Letters·F J Jiménez-JiménezR Codoceo
Jan 1, 1991·Free Radical Biology & Medicine·C K Chow
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
May 23, 1998·Neurochemistry International·J L Cadet, C Brannock
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I Cantuti-CastelvetriJ A Joseph
Sep 5, 2003·Journal of Chemical Neuroanatomy·Jane A FosterRobert A Levine
Oct 12, 2001·Free Radical Biology & Medicine·E Méndez-AlvarezJ L Labandeira-García
Apr 18, 2002·Biochimica Et Biophysica Acta·Estefanía Méndez-AlvarezJosé Luis Labandeira-García
Oct 8, 1999·Journal of the American College of Nutrition·K N PrasadB Kumar
Jun 27, 2003·Neurotoxicity Research·Jaime Fornaguera, Rainer K W Schwarting
May 14, 2005·Antioxidants & Redox Signaling·Clifford W Shults
Nov 1, 1990·The Journal of Pharmacy and Pharmacology·C RamassamyJ Costentin
Jan 8, 2011·Molecular Neurodegeneration·Alison I BernsteinKaren L O'Malley
Jul 23, 2003·CNS Drugs·Silvia MandelMoussa B H Youdim

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