Vitamin E for antipsychotic-induced tardive dyskinesia

The Cochrane Database of Systematic Reviews
Karla Soares-WeiserHanna Bergman

Abstract

Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. Vitamin E has been proposed as a treatment to prevent or decrease TD. The primary objective was to determine the clinical effects of vitamin E in people with schizophrenia or other chronic mental illness who had developed antipsychotic-induced TD.The secondary objectives were:1. to examine whether the effect of vitamin E was maintained as duration of follow-up increased;2. to test the hypothesis that the use of vitamin E is most effective for those with early onset TD (less than five years) SEARCH METHODS: We searched the Cochrane Schizophrenia Group Trials Register (July 2015 and April 2017), inspected references of all identified studies for further trials and contacted authors of trials for additional information. We included reports if they were controlled trials dealing with people with antipsychotic-induced TD and schizophrenia who remained on their antipsychotic medication and had been randomly allocated to either vitam...Continue Reading

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Citations

Apr 18, 2018·The Cochrane Database of Systematic Reviews·Samer AlabedHanna Bergman
May 31, 2019·Systematic Reviews·Farhad Shokraneh, Clive E Adams
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Stanley N Caroff
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Related Concepts

Dyskinesia, Medication-Induced
Health Care Seeking Behavior
Schizophreniform Disorders
Schizophrenia
Antipsychotic Effect
Vitamin E
Vitamins
Controlled Clinical Trials, Randomized
Disease Progression
Clinical Trials

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