Vitamin E in heart transplantation: effects on cardiac gene expression

Transplantation
Ingo SchulteJürgen Borlak

Abstract

Oxidative stress, as induced in organ storage or upon reperfusion, may impact the quality of the transplant. Vitamin E, a radical scavenger, may alleviate stress associated with cardiac surgery. We investigated the effects of vitamin E treatment in a rat heart transplantation model and link dose to tissue and plasma vitamin E levels. We further studied expression of 39 genes coding for stress markers, proinflammatory cytokines, apoptotic pathways, structural proteins, extracellular matrix, cardiomyocyte specific transcription factors, and metabolic pathways to obtain information on the benefits of vitamin E treatment. Treatment of donor and recipient animals significantly increased blood and heart tissue vitamin E levels (P<0.05). We observed a significant reduction (P<0.05) of genes coding for oxygen detoxification (e.g., SOD), as well as expression of the adhesion molecules, ICAM-1 and PECAM-1 (P<0.05). Notably, transcript levels of the stress marker atrial natriuretic peptide (ANP) was reduced (P<0.05), whereas expression of cardiac and skeletal actin was increased. Further, expression of the disease markers beta-MHC and VCAM-1 was repressed (P<0.05), as was expression of the myocyte enhancer factor MEF2c. Noteworthy, vitami...Continue Reading

References

Jun 21, 1995·JAMA : the Journal of the American Medical Association·H N HodisS P Azen
Mar 6, 1996·JAMA : the Journal of the American Medical Association·J M RapolaJ K Huttunen
Jan 1, 1996·Free Radical Biology & Medicine·R K LiG W Burton
Apr 29, 1998·Journal of Hypertension·C GrohéH Vetter
Mar 27, 1999·Biochemical and Biophysical Research Communications·T YanL W Oberley
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsP Sleight
Feb 11, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P FerberD Tschöpe
May 4, 2000·Progress in Lipid Research·X Wang, P J Quinn
Jun 6, 2000·The American Journal of Clinical Nutrition·M A Beck
Feb 13, 2001·The Journal of Nutrition·J E Freedman, J F Keaney
Feb 22, 2001·Biochemical and Biophysical Research Communications·H JänkäläT Mäki
Apr 3, 2001·Free Radical Biology & Medicine·S J ChangH H Chen
May 23, 2001·Experimental Biology and Medicine·N KaulI Jialal
Feb 9, 2002·The Annals of Thoracic Surgery·David P NelsonEllis J Neufeld
Feb 14, 2002·Journal of Applied Physiology·Anselm T BäumerMichael Böhm
Feb 16, 2002·Biochemical and Biophysical Research Communications·Hongjiang ChenJawahar L Mehta
May 30, 2002·Biological Chemistry·Roberta RicciarelliAngelo Azzi
Sep 27, 2002·The American Journal of Clinical Nutrition·Regina Brigelius-FlohéAngelo Azzi
Oct 4, 2002·Nutrition·Yun-Zhong FangGuoyao Wu
Feb 26, 2003·The American Journal of Clinical Nutrition·Meilin LiuTom Saldeen
Apr 26, 2003·Hybridoma and Hybridomics·E KroumpouzouP Toutouzas
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David G RabkinHenry M Spotnitz
Jan 13, 2004·Circulation Research·Michael J Ryan, Curt D Sigmund
Apr 20, 2004·Journal of Cellular and Molecular Medicine·Adelina MunteanuA Azzi
Feb 5, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gábor SzabóSiegfried Hagl
Jul 7, 2005·JAMA : the Journal of the American Medical Association·I-Min LeeJulie E Buring

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Citations

Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
Feb 15, 2011·Human & Experimental Toxicology·Maria Carolina M O NascimentoAna Lucia A Ferreira
Sep 29, 2006·World Journal of Gastroenterology : WJG·Chun-Hui LiWen-Xie Xu

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