Vitamin E intake, α-tocopherol levels and pulmonary function in children and adolescents with cystic fibrosis

The British Journal of Nutrition
Janna W WoestenenkRoderick H J Houwen

Abstract

Pancreatic insufficiency cystic fibrosis (CF) patients receive vitamin E supplementation according to CF-specific recommendations in order to prevent deficiencies. It has been suggested that higher serum α-tocopherol levels could have protective effects on pulmonary function (PF) in patients with CF. Whether current recommendations are indeed optimal for preventing deficiency and whether vitamin E has therapeutic benefits are subjects of debate. Therefore, we studied vitamin E intake as well as the long-term effects of vitamin E intake, the coefficient of fat absorption (CFA) and IgG on α-tocopherol levels. We also examined the long-term effects of serum α-tocopherol and serum IgG on forced expiratory volume in 1 s expressed as percentage of predicted (FEV₁% pred.) in paediatric CF patients during a 7-year follow-up period. We found that CF patients failed to meet the CF-specific vitamin E recommendations, but serum α-tocopherol below the 2·5th percentile was found in only twenty-three of the 1022 measurements (2 %). Furthermore, no clear effect of vitamin E intake or the CFA on serum α-tocopherol was found (both P≥ 0·103). FEV₁% pred. was longitudinally inversely associated with age (P< 0·001) and serum IgG (P= 0·003), but it ...Continue Reading

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Citations

Mar 7, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Mathieu GruetSamuel Verges

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