PMID: 9537283Apr 16, 1998Paper

Vitamin E modulation of dieldrin-induced hepatic focal lesion growth in mice

Journal of Toxicology and Environmental Health. Part a
K L KolajaJ E Klaunig

Abstract

The effect of vitamin E on dieldrin-induced hepatic focal lesion growth in male B6C3F1 mice previously treated with diethylnitrosamine (DEN) was investigated. After hepatic focal lesions were formed, mice were placed into one of the following treatment groups: Group 1, 50 mg vitamin E/kg diet (control NIH-07 diet); Group 2, 10 mg dieldrin/kg NIH-07 diet; Group 3, 10 mg dieldrin and 450 mg vitamin E/kg NIH-07 diet; and Group 4, 450 mg vitamin E/kg NIH-07 diet. Mice were killed and necropsied after 30 and 60 d of dietary treatment. The effect of treatment on lesion growth was examined by measuring the number of focal lesions per liver and the relative hepatic focal lesion volume. In addition, the possible cellular mechanism of focal hepatocyte growth was investigated by examining both focal DNA synthesis and apoptosis. Dieldrin treatment alone (Group 2) increased the focal lesion volume, focal lesion number, and focal lesion labeling index. Supplementation with vitamin E (Group 3) blocked this effect. Vitamin E supplementation to the diet alone (Group 4) also enhanced focal lesion growth and increased the number of lesions per liver, the relative focal volume, and the labeling index in hepatic focal lesions. Interestingly, vitami...Continue Reading

Citations

Dec 12, 2001·Toxicology Letters·Joungjoa ParkJames E Klaunig
Nov 11, 1999·Toxicology Letters·D E StevensonJ E Klaunig
Feb 24, 2001·Antioxidants & Redox Signaling·C B Ambrosone
Jul 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jun LiHoward P Glauert
Apr 6, 1999·Carcinogenesis·R P HuangA L Boynton

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