Vitamin E provides protection for bone in mature hindlimb unloaded male rats

Calcified Tissue International
B J SmithB H Arjmandi

Abstract

The deleterious effects of skeletal unloading on bone mass and strength may, in part, result from increased production of oxygen-derived free radicals and proinflammatory cytokines. This study was designed to evaluate the ability of vitamin E (alpha-tocopherol), a free-radical scavenger with antiinflammatory properties, to protect against bone loss caused by skeletal unloading in mature male Sprague-Dawley rats. A 2 x 3 factorial design was used with either hindlimb unloading (HU) or normal loading (ambulatory; AMB), and low-dose (LD; 15 IU/kg diet), adequate-dose (AD; 75 IU/kg diet), or high-dose (HD; 500 IU/kg diet) vitamin E (DL-alpha-tocopherol acetate). To optimize the effects of vitamin E on bone, dietary treatments were initiated 9 weeks prior to unloading and continued during the 4-week unloading period, at which time animals were euthanized and blood and tissue samples were collected. Serum vitamin E was dose-dependently increased, confirming the vitamin E status of animals. The HD treatment improved oxidation parameters, as indicated by elevated serum ferric-reducing ability and a trend toward reducing tissue lipid peroxidation. Histomorphometric analysis of the distal femur revealed significant reductions in trabecul...Continue Reading

References

Sep 1, 1978·Annals of Internal Medicine·J F AloiaK Ellis
Sep 1, 1990·Research Quarterly for Exercise and Sport·R E Rikli, B G McManis
Sep 1, 1990·The American Journal of Clinical Nutrition·S N MeydaniJ B Blumberg
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D LeblancJ M Krebs
Mar 1, 1990·The Journal of Clinical Investigation·I R GarrettG R Mundy
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R K GlobusE Morey-Holton
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Dec 1, 1970·Metabolism: Clinical and Experimental·C L DonaldsonD E McMillan
Jan 3, 1980·Biochimica Et Biophysica Acta·M NishikimiK Yagi
Oct 1, 1983·Archives of Biochemistry and Biophysics·K Fukuzawa, J M Gebicki
Jan 1, 1980·Calcified Tissue International·J H Dominguez, G R Mundy
Oct 1, 1995·Acta Orthopaedica Scandinavica·E GöktürkZ Gülbas
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D D BikleB P Halloran
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P M FallL G Raisz
Nov 1, 1994·The American Journal of Clinical Nutrition·S N MeydaniJ B Blumberg
Aug 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E I BarengoltsS C Kukreja
Oct 1, 1995·Calcified Tissue International·H XuM F Seifert
Oct 1, 1996·Medicine and Science in Sports and Exercise·K M BaldwinC M Snow
Feb 26, 1998·Journal of Applied Physiology·K C WesterlindR T Turner
Jun 30, 1998·Endocrinology·K TraianedesL F Bonewald
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J W ChowS W Fox
May 9, 2000·Progress in Lipid Research·A Azzi, A Stocker
Jun 27, 2000·The Journal of Nutrition·A AzziJ M Zingg
Feb 13, 2001·The Journal of Nutrition·D WuS Meydani
Mar 7, 2001·Hypertension·A D DobrianR L Prewitt
Mar 15, 2001·Journal of Applied Physiology·K M BuhlH J Donahue
Jul 17, 2001·Immunology·R J van't Hof, S H Ralston
Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A E NicogossianR Teeter
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R RicciarelliA Azzi
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Birgit Heller-StilbDieter Häussinger
Feb 2, 2002·The Journal of Nutrition·Brenda J SmithBarbara J Stoecker
Mar 16, 2002·Journal of Applied Physiology·Emily R Morey-Holton, Ruth K Globus
May 30, 2002·Biological Chemistry·Roberta RicciarelliAngelo Azzi

❮ Previous
Next ❯

Citations

Oct 12, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stephanie M DurbinJanet C Tou
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Isa Naina MohamedNur Farhana Mohd Fozi
Oct 2, 2012·Head & Face Medicine·Kent UrbanUNKNOWN Biomineralisation Research Unit
Mar 11, 2010·The Journal of Veterinary Medical Science·Satoshi SoetaHajime Aamsaki
May 21, 2013·Journal of Bone and Mineral Metabolism·Stephanie M DurbinJanet C Tou
Oct 4, 2013·Journal of Osteoporosis·Rafaela G FeresinBahram H Arjmandi
Apr 15, 2014·Nutrients·Kok-Yong Chin, Soelaiman Ima-Nirwana
Nov 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chen-Rui LiQi-Bing Mei
Jan 31, 2009·Aging Clinical and Experimental Research·Sheau C ChaiBahram H Arjmandi
Dec 27, 2015·Pharmacology & Therapeutics·Hong Yong PehW S Fred Wong
Feb 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maryam S HamidiAngela M Cheung
Sep 21, 2013·Free Radical Biology & Medicine·Urszula T IwaniecMaret G Traber
Mar 1, 2016·Food & Function·Sarah A JohnsonBahram H Arjmandi
Oct 6, 2017·International Journal of Molecular Sciences·Israel Pérez-TorresMaría Esther Rubio-Ruiz
Jun 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuanghong SongPeng Shang
Oct 13, 2017·European Journal of Oral Sciences·Maryam TorshabiSamira Sotoudeh
Oct 26, 2018·Calcified Tissue International·Mackenzie L HaganMeghan E McGee-Lawrence
Apr 6, 2007·The British Journal of Nutrition·Caroline PuelVéronique Coxam
Jul 1, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Iman MomkenStéphane Blanc
Oct 26, 2018·PloS One·Sheau C ChaiBahram H Arjmandi
Dec 3, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ZhangJ Zhang
Mar 27, 2019·International Journal of Molecular Sciences·Sok Kuan WongSoelaiman Ima-Nirwana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
M NorazlinaB A Khalid
Evidence-based Complementary and Alternative Medicine : ECAM
Norliza MuhammadIma-Nirwana Soelaiman
The Journal of Nutritional Biochemistry
B H ArjmandiSimin Meydani
Journal of Bone and Mineral Metabolism
Ahmad Nazrun ShuidIma Nirwana Soelaiman
© 2022 Meta ULC. All rights reserved