Vitamin E status and associations in maternal-infant Dyads in the Midwestern United States

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Corrine HansonAnn Anderson-Berry

Abstract

Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn outcomes. Vitamin E status was evaluated in 189 mother-infant pairs. Concentrations of α-, γ- and δ-tocopherol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Linear and logistic regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Maternal and cord serum tocopherol concentrations were positively correlated for γ-tocopherol (r = 0.32, p ˂ 0.001) and δ-tocopherol (r = 0.46, p ˂ 0.001) but not for α-tocopherol. After adjustment for confounders, maternal concentrations of tocopherols were positively associated with Apgar scores (p = 0.02) and infant growth parameters at birth. Conversely, cord tocopherol levels were inversely associated with Apgar scores (p = 0.02)...Continue Reading

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