Vitamin E: supplement versus diet in neurodegenerative diseases

Trends in Molecular Medicine
Liang Shen, Hong-Fang Ji

Abstract

Contradicting outcomes have been observed in numerous studies investigating the benefits of vitamin E supplements in the context of neurodegenerative diseases. By reviewing epidemiological studies and clinical trials, it is found that dietary intake of vitamin E exhibits beneficial effects on neurodegeneration, whereas α-tocopherol supplements failed in most interventional trials. Potential reasons for why α-tocopherol supplements exhibit disappointing effects, especially compared with dietary intake, are put forward and implications for future studies are discussed.

References

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Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Jul 14, 2010·Archives of Neurology·Elizabeth E DevoreMonique M B Breteler

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Citations

Oct 31, 2015·Expert Opinion on Therapeutic Patents·Maria Koufaki
Apr 2, 2016·Neural Plasticity·Pedro LobosAndrea Paula-Lima

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