Vitamin E supplementation ameliorates aflatoxin B1-induced nephrotoxicity in rats

Acta histochemica
Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany

Abstract

Fungal toxins in nutrition can cause organ dysfunction or even failure. Aflatoxin B1 (AFB1)-induced renal impairment is not sufficiently studied regarding its extent and prevention. The aim of this experiment was to study the effect of AFB1 on renal cortical tissue and whether its possible harmful effect could be prevented by the conventional economical antioxidant, vitamin E. Forty rats were divided into four groups; I-IV. Group I represented the control while the others received vitamin E (Vit E), AFB1 and AFB1+Vit E, respectively. Renal cortex specimens were taken from each group after 25 days. Then, specimens were prepared for histological study by hematoxlyin and eosin (H&E), Masson's trichrome, caspase-3 as well as for ultrastructural examination and oxidative stress parameters evaluation. Data were morphometrically and statistically analyzed. In AFB1-treated group, focal tubulo-interstitial affection in the form of tubular cytoplasmic vacuolation, mitochondrial disruption, numerous lysosomes, marked increase in collagen deposition and in caspase-3 expression were observed. Glomerular impairment in the form of fusion of podocytes enlarged foot processes and thickening of the glomerular basement membrane (GBM) with loss of...Continue Reading

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Citations

Jun 25, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yaqi DaiWentao Xu
Oct 11, 2017·Environmental Science and Pollution Research International·Gökhan EraslanMürsel Karabacak
May 23, 2019·Journal of Biochemical and Molecular Toxicology·Bahareh HakiminiaAzadeh Moghaddas
Jun 6, 2021·Environmental Toxicology·Nomali Zanele DlaminiRene B Khan
Aug 22, 2021·BioFactors·Roghayeh YahyazadehVahid Reza Askari

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