PMID: 2203257Sep 1, 1990Paper

Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects

The American Journal of Clinical Nutrition
S N MeydaniJ B Blumberg

Abstract

The effect of vitamin E supplementation on the immune response of healthy older adults was studied in a double-blind, placebo-controlled trial. Subjects (n = 32) resided in a metabolic research unit and received placebo or vitamin E (800 mg dl-alpha-tocopheryl acetate) for 30 d. Alpha-tocopherol content of plasma and peripheral blood mononuclear cells (PBMCs), delayed-type hypersensitivity skin test (DTH), mitogen-stimulated lymphocyte proliferation, as well as interleukin (IL)-1, IL-2, prostaglandin (PG) E2, and serum lipid peroxides were evaluated before and after treatment. In the vitamin E-supplemented group 1) alpha-tocopherol content was significantly higher (p less than 0.0001) in plasma and PBMCs, 2) cumulative diameter and number of positive antigen responses in DTH response were elevated (p less than 0.05), 3) IL-2 production and mitogenic response to optimal doses of concanavalin A were increased (p less than 0.05), and 4) PGE2 synthesis by PBMCs (p less than 0.005) and plasma lipid peroxides (p less than 0.001) were reduced. Short-term vitamin E supplementation improves immune responsiveness in healthy elderly individuals; this effect appears to be mediated by a decrease in PGE2 and/or other lipid-peroxidation produ...Continue Reading

Citations

Nov 1, 1994·The Proceedings of the Nutrition Society·P A MorrisseyP J Sheehy
Sep 1, 1993·Journal of Dairy Science·A Bendich
Mar 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A MartinM Meydani
Jan 22, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A J ClaxtonK R Feingold
Mar 3, 1998·Nutrition Reviews·M Meydani
Mar 3, 1998·Nutrition Reviews·B M LesourdM Ferry
Mar 30, 1999·The Proceedings of the Nutrition Society·D Wu, S N Meydani
Dec 22, 1999·The Proceedings of the Nutrition Society·B Lesourd, L Mazari
Aug 17, 2000·The Journal of Infectious Diseases·S N Han, S N Meydani
Dec 29, 2000·Annals of the New York Academy of Sciences·W Fawzi
May 15, 2001·American Journal of Physiology. Cell Physiology·E W PetersenB K Pedersen
May 3, 2001·The American Journal of Clinical Nutrition·E BoelsmaL Roza
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·O AdolfssonS N Meydani
Mar 14, 2002·Asia Pacific Journal of Clinical Nutrition·Clifford AbiakaAmos Simbeye
May 31, 2002·The American Journal of Clinical Nutrition·Michele L Dreyfuss, Wafaie W Fawzi
Jul 23, 2002·The Proceedings of the Nutrition Society·Mohsen Meydani
Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Robert F Grimble
Jun 28, 2003·American Journal of Veterinary Research·Jean A HallRosemary C Wander
Oct 7, 2004·Critical Reviews in Food Science and Nutrition·Joye K WillcoxGeorge L Catignani
Mar 9, 2005·Annals of the New York Academy of Sciences·Simin Nikbin MeydaniDavidson H Hamer
Apr 9, 2005·The American Journal of Clinical Nutrition·Eduardo VillamorWafaie W Fawzi
Sep 24, 2005·The British Journal of Nutrition·Ruud AlbersBernhard Watzl
Nov 23, 2006·Antioxidants & Redox Signaling·Agnieszka SiomekRyszard Olinski
May 13, 2008·The American Journal of Clinical Nutrition·Emmanuelle E FabreValerie Nivet-Antoine
Jan 31, 2009·Aging Clinical and Experimental Research·Sheau C ChaiBahram H Arjmandi
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Simin Nikbin Meydani, Dayong Wu
Aug 14, 2012·Journal of the American Geriatrics Society·Sarah E ForsterElizabeth A Williams
Sep 1, 2020·Aging Clinical and Experimental Research·Sirio FiorinoDario de Biase
Dec 1, 1992·Nutrition Reviews·R K Chandra
Apr 1, 1995·Nutrition Reviews·R Chandra
Aug 1, 1993·Nutrition Reviews·L C Rall, S N Meydani
Mar 3, 1998·Nutrition Reviews·S N Meydani, A A Beharka
Dec 22, 1999·The Proceedings of the Nutrition Society·S N Han, S N Meydani
Feb 3, 1999·Annals of the New York Academy of Sciences·M MeydaniS N Meydani

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