Vitamin E supplementation in pregnancy.

The Cochrane Database of Systematic Reviews
A RumboldCaroline A Crowther

Abstract

Vitamin E supplementation may help reduce the risk of pregnancy complications involving oxidative stress, such as pre-eclampsia. There is a need to evaluate the efficacy and safety of vitamin E supplementation in pregnancy. To assess the effects of vitamin E supplementation, alone or in combination with other separate supplements, on pregnancy outcomes, adverse events, side effects and use of health services. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2015) and reference lists of retrieved studies. All randomised or quasi-randomised controlled trials evaluating vitamin E supplementation in pregnant women. We excluded interventions using a multivitamin supplement that contained vitamin E. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. Twenty-one trials, involving 22,129 women were eligible for this review. Four trials did not contribute data. All of the remaining 17 trials assessed vitamin E in combination with vitamin C and/or other agents. Overall the risk of bias ranged from low to unclear to high; 10 trials were judged to be at low risk of bias, six trials to be at unclear risk of bias and five trials to b...Continue Reading

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Citations

May 23, 2016·Current Cardiology Reports·J L BrowneD E Grobbee
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Nancy MedleyZarko Alfirevic
Mar 8, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mayara Caldeira-DiasValéria C Sandrim
May 21, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Henry DasingerDavid L Mattson
Nov 22, 2018·Frontiers in Physiology·Martin AlcalaMarta Viana
Nov 17, 2017·BMC Public Health·Hannah BlencoweZulfiqar A Bhutta
Dec 2, 2020·Epilepsy & Behavior : E&B·Hyeok Hee KwonJoon Won Kang
Mar 7, 2021·Nutrients·Marie JouanneAnne Sophie Voisin-Chiret
Jul 1, 2021·Nature Communications·Allison L FisherElizabeta Nemeth

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