Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M MaccarroneM Taccone-Gallucci

Abstract

A number of pathological conditions caused by oxidative stress have been reported in uremic patients undergoing maintenance hemodialysis (HD). Enhanced lipid peroxidation was previously observed in peripheral blood mononuclear cells (PBMCs) of HD patients. Upregulation of 5-lipoxygenase (5-Lox) activity and protein content with enhanced production of leukotriene B(4) (LTB(4)) and membrane lipoperoxides was also shown in PBMCs of HD patients. Administration of free vitamin E specifically inhibited 5-Lox activity without affecting gene expression at the protein level. To assess whether oral or intramuscular (IM) administration of vitamin E may suppress 5-Lox in HD patients, PBMCs from 16 subjects on maintenance HD therapy for at least 6 months were investigated before and after a short course of IM or oral administration of vitamin E (8 patients per group). PBMCs from 13 healthy controls were also evaluated and assumed as the reference standard. Vitamin E significantly reduced lipid peroxidation, LTB(4) content, and 5-Lox activity in PBMCs, whereas 5-Lox gene expression at the protein level was not affected. There were no significant differences in these parameters between patients treated with IM or oral vitamin E. PBMCs of HD p...Continue Reading

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Citations

Dec 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohamed Alaa Thabet, James C M Chan
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shuichi TsuruokaAkio Fujimura
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Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mauro MaccarroneMassimo Taccone-Gallucci
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Sep 24, 2021·Journal of Neurochemistry·Md JakariaScott Ayton

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