Vitamin E trafficking

Annals of the New York Academy of Sciences
Maret G TraberRobert L Hamilton

Abstract

The alpha-tocopherol transfer protein (alpha-TTP) is required to prevent vitamin E deficiency in humans and in alpha-TTP null mice. Whereas alpha-TTP is not required to facilitate intestinal absorption of vitamin E, it is required to maintain normal alpha-tocopherol concentrations in plasma and extrahepatic tissues. alpha-Tocopherol secretion from the liver in very low density lipoproteins (VLDLs) is impaired in humans with a defect in the alpha-TTP gene. In perfusions of isolated cynomolgus monkey livers, VLDLs were preferentially enriched in RRR-alpha-tocopherol. The mechanism by which alpha-TTP incorporates alpha-tocopherol into nascent VLDLs is the topic of this report. VLDL assembly is a multistep secretory process that occurs within the membrane compartments of the endoplasmic reticulum and Golgi apparatus. Thus, we postulated that alpha-TTP might transfer alpha-tocopherol onto nascent VLDLs either in the endoplasmic reticulum or in the Golgi apparatus. To test these possibilities, we isolated nascent VLDLs from highly purified RER and Golgi apparatus membrane fractions from livers of rats fed equimolar ratios of RRR- and SRR-alpha-tocopherols labeled with different amounts of deuterium. Although the plasma was enriched i...Continue Reading

References

Sep 1, 1992·Lipids·Maret G TraberH Kayden
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard J Havel, R L Hamilton
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G RenaudRichard J Havel
Mar 1, 1989·The American Journal of Clinical Nutrition·Maret G Traber, H Kayden
Sep 25, 1987·Biochimica Et Biophysica Acta·A BjørneboeC A Drevon
Oct 1, 1993·Protein Expression and Purification·J KuhlenkampN Kaplowitz
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·M AritaK Inoue
Mar 21, 1998·Archives of Biochemistry and Biophysics·Debbie J MustacichD J Reed
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y TerasawaR V Farese
May 23, 2001·Circulation Research·C DongP J Goldschmidt-Clermont
Sep 8, 2001·The Journal of Biological Chemistry·J F OramR Stocker
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Takanori YokotaH Arai
Jul 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Xiao Ping YangXian-Cheng Jiang
Aug 6, 2003·Journal of Molecular Biology·Reto MeierAchim Stocker
Aug 1, 1954·The American Journal of Physiology·L A LEWISI H PAGE
Oct 9, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masakuni HoriguchiHiroyuki Arai
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·K Christopher MinWayne A Hendrickson
Feb 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Richard J Havel, Robert L Hamilton
Feb 14, 2004·Journal of Cell Science·Thomas PomorskiGerrit van Meer
Apr 7, 2004·Biochemistry·Samantha MorleyDanny Manor

Citations

Oct 26, 2011·The British Journal of Nutrition·Jens RailaGetu Abraham
Apr 8, 2010·Critical Reviews in Food Science and Nutrition·Zorabel CorderoHeiner Boeing
Jun 15, 2006·Antioxidants & Redox Signaling·Pramod KhoslaChandan K Sen
Aug 29, 2012·Journal of Veterinary Internal Medicine·C J Finno, S J Valberg
Jan 23, 2009·American Journal of Physiology. Endocrinology and Metabolism·Jahangir Iqbal, M Mahmood Hussain
Jul 14, 2010·Reproductive Biology and Endocrinology : RB&E·Ramanathan K KasimanickamCraig D Thatcher
Feb 2, 2012·Journal of Nutritional Science and Vitaminology·Tomono UchidaSaiko Ikeda
Oct 14, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shoji KatsudaMasakazu Yamagishi
May 18, 2007·Molecular Aspects of Medicine·Chandan K SenSashwati Roy
Dec 5, 2006·The Journal of Nutritional Biochemistry·Richard S BrunoEmily Ho
Feb 27, 2007·Molecular Aspects of Medicine·Attilio Rigotti
Jan 21, 2010·Molecular Nutrition & Food Research·Nadine CrouzinMichel Vignes
Jan 29, 2010·BioFactors·Francesco Galli, Angelo Azzi
Mar 6, 2010·Molecular Nutrition & Food Research·Ruth BanksColin Selman
Oct 31, 2012·Free Radical Biology & Medicine·Gayatri SharmaKevin Mills
Jun 4, 2010·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Elizabeth BrownCristina Holt
May 20, 2006·Journal of Lipid Research·Kaori Minehira-CastelliStephen G Young
Mar 19, 2013·Journal of Lipid Research·Maret G Traber
Jun 22, 2007·Journal of Lipid Research·Kamran AnwarM Mahmood Hussain
Mar 17, 2016·World Journal of Biological Chemistry·Lisa SchmölzMaria Wallert
Mar 17, 2012·BioFactors·Yash B Joshi, Domenico Praticò
Jul 15, 2005·Molecular and Cellular Biochemistry·May Al-MaghrebiMary S Thompson
Jul 19, 2008·Molecular and Cellular Biochemistry·Francis C LauDebasis Bagchi

Related Concepts

Ttpa protein, mouse
Biliary Sludge
Carrier Proteins
Plasma Membrane
Endocytosis
Golgi Apparatus
Lipoproteins, VLDL1
Liver
Endosomes
Vitamin E

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.