Vitamin K antagonist therapy: changes in the treated populations and in management results in Italian anticoagulation clinics compared with those recorded 20 years ago

Internal and Emergency Medicine
G Palareticenters participating in the FCSA-START-Register (The ISCOAT 2016 study: Italian Study on Complications of Oral Anticoagulan

Abstract

Vitamin K antagonists (VKA) are the most widely used anticoagulants in the world. An appropriate management of treated patients is crucial for their efficacy and safety. The prospective, observational, multicenter, inception-cohort FCSA-START Register, a branch of START Register (NCT02219984) included VKA-treated patients managed by centers of Italian Federation of anticoagulation clinics (AC). Baseline patient characteristics and data during treatment were analyzed and compared with those of ISCOAT study, performed by the Federation and published in 1996/7. 5707 naïve patients [53% males, mean age 73.0 years (28.1% >80 years)], 61.6% treated for atrial fibrillation (AF), and 28.0% for venous thromboembolism were included. During the 8906 patient-years (pt-yrs) of observation, 123 patients had major bleeding (MB) (1.38% pt-yrs; fatal: 0.11% pt-yrs), while non-major clinically relevant bleeds were 144 (1.62% pt-yrs). Bleeding was more frequent in elderly (≥70 years; p = 0.04), and during initial 3-month therapy (p = 0.02). Bleeding rate was 2.5% pt-yrs for temporally related INR results <3.0, increasing to 12.5% for INR ≥ 4.5. Thrombotic events were 47 (0.53% pt-yrs; 4 fatal 0.04% pt-yrs). Compared with ISCOAT-1996/7 results, pa...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
May 28, 2009·Circulation·V PengoUNKNOWN Italian Federation of Centers for the Diagnosis of Thrombosis and Management of Antithrombotic Therapies (FCSA)
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Nov 28, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tara GomesDavid N Juurlink
Feb 27, 2015·Thrombosis and Haemostasis·Vilhelm SjögrenAnders Själander
May 23, 2015·PloS One·Emilia AntonucciUNKNOWN START-Register

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Citations

Aug 6, 2017·Internal and Emergency Medicine·Francesco DentaliMonica Gianni
Sep 27, 2018·Expert Review of Hematology·Gualtiero Palareti, Daniela Poli
Mar 4, 2018·Internal and Emergency Medicine·Francesco Marongiu, Doris Barcellona
Dec 7, 2018·Hematology·Walter Ageno, Marco Donadini
Dec 7, 2018·Hematology·Vittorio Pengo, Gentian Denas
Jul 21, 2020·Internal and Emergency Medicine·Doris Barcellona, Francesco Marongiu
Feb 2, 2019·Clinical Oral Investigations·Federico BertonRoberto Di Lenarda
Aug 31, 2019·Future Cardiology·Olga Gavín SebastiánLuis Palomera Bernal
Jun 28, 2019·Internal and Emergency Medicine·Irene MarzonaMaria Carla Roncaglioni
Mar 12, 2021·International Journal of Cardiology·Doris BarcellonaFrancesco Marongiu

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Clinical Trials Mentioned

NCT02219984

Software Mentioned

ISCOAT
SPSS

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