Vitamin K deficiency in diarrhoea

Indian Journal of Pediatrics
R KumarG Garewal

Abstract

The study was undertaken to determine the frequency of occurrence of vitamin K deficiency in infants with diarrhoeal illness. Infants were categorized into four groups as follows: A(acute diarrhoea), B(protracted diarrhoea) C(intractable diarrhoea) and D(healthy controls). Screening coagulation tests, PT and PTTK along with estimation of functional activity and total antigenic levels of prothrombin were performed. The ratio of functional to total prothrombin was calculated. PT was prolonged in 30% (24/75) of all infants with diarrhoea as compared to controls where the abnormality was observed in 11.1% infants (2/18). The ratio of functional to total prothrombin was significantly lower in infants with diarrhoea, the mean +/- SD values being 0.65 +/- 0.41 vs 1.1 +/- 0.26. This difference was statistically highly significant (p < 0.001). Low ratio was observed in 57.3% (43/75) infants with diarrhoea. Thus functional to total prothrombin ratio identified approximately twice as many diarrhoeal infants with vitamin K deficiency as compared to PT alone. There was no significant correlation with breast feeding as the only mode of diet, or the prior administration of antibiotics in infants with diarrhoea. The inherent malabsorptive stat...Continue Reading

References

Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
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Aug 1, 1970·Archives of Disease in Childhood·N MatsaniotisC Vlachou
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Jun 1, 1946·American Journal of Diseases of Children·S RAPOPORT, K DODD

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Citations

Aug 17, 2006·Advances in Therapy·Ali BayAbdurahman Uner
May 24, 2011·Journal of Paediatrics and Child Health·Sebahat YılmazPeyami Cinaz
Jan 1, 2010·Indian Journal of Psychiatry·Prasad G Rao
May 9, 2009·Neurological Research·Mohammad Taghi GhorbanianYaghoub Fathollahi

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