PMID: 3761086Oct 1, 1986Paper

Vitamin K deficiency in the newborn infant: prevalence and perinatal risk factors

The Journal of Pediatrics
A D ShapiroW E Hathaway

Abstract

The prevalence of vitamin K deficiency in newborn infants and the influence of perinatal risk factors were studied prospectively in 934 infants. A noncarboxylated prothrombin assay to detect proteins induced in vitamin K absence (PIVKA-II) was used to determine the presence of vitamin K deficiency; of 934 cord blood samples assayed, 2.9% were positive for PIVKA-II (0.015 to 0.15 U/ml). All infants found to have detectable PIVKA-II were born at term. The number of infants positive for PIVKA-II was greater in the group small for gestational age (7.4%) than in those appropriate (2.7%) or large (3.1%) for gestational age. Nine categories of perinatal risk groups were defined: however, the majority of infants who were PIVKA-II positive (63%) were normal. All infants received prophylactic vitamin K, and no infant with PIVKA-II in the cord sample subsequently had clinical bleeding. In two patients the rate of 50% disappearance of PIVKA-II after vitamin K administration approximated 70 hours. Two PIVKA-II positive patients with active bleeding or disseminated intravascular coagulation had an accelerated disappearance of 20 to 40 hours. The long disappearance time of PIVKA-II in a steady state may allow detection of vitamin K deficiency...Continue Reading

References

Nov 1, 1979·Pediatric Research·W MunteanI D Mutz
Dec 1, 1979·Pediatric Research·D R BarnardW E Hathaway
Aug 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·A L Pietersma-de Bruyn, P M van Haard
Mar 1, 1985·The Journal of Pediatrics·P A Lane, W E Hathaway
Jun 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·P M AtkinsonN P Walker
Jan 1, 1982·Thrombosis Research·T Meguro, K Yamada

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Citations

Mar 1, 1993·Journal of Clinical Pharmacology·S Kacew
Feb 1, 1988·European Journal of Pediatrics·R von KriesU Göbel
Nov 1, 1991·The Journal of Pediatrics·M J Manco-JohnsonR A Marlar
Aug 1, 1988·The Journal of Pediatrics·M J Manco-JohnsonB A Warady
Apr 1, 1991·Baillière's Clinical Haematology·M Andrew
Jun 1, 1990·British Journal of Haematology·M J Shearer
Apr 1, 1992·Acta Paediatrica Japonica; Overseas Edition·T NakagawaK Watanabe
Oct 1, 1991·Acta paediatrica Scandinavica·H Ekelund
Apr 1, 1989·Archives of Disease in Childhood·B Gibson
Jun 24, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·M SalonvaaraK Heinonen
Aug 1, 1993·American Journal of Public Health·T H TulchinskyJ V Linden
Sep 1, 1988·American Journal of Obstetrics and Gynecology·W J MoralesF Marsalisi
Jun 1, 1992·Blood Reviews·M J Shearer
Oct 1, 1990·Baillière's Clinical Haematology·V BlanchetteM Andrew
Aug 1, 1989·Acta Paediatrica Japonica; Overseas Edition·I MatsudaT Ogata
Oct 25, 2007·Pediatric Blood & Cancer·Veronica H FloodLynn K Boshkov
Dec 4, 2009·Journal of Pediatric Hematology/oncology·Smadar Eventov-FriedmanEric S Shinwell
Oct 3, 2002·Pediatric Research·Marilyn J Manco-JohnsonWilliam Hay

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